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Atg6 Autophagy-related 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42850, updated on 4-Jan-2025

Summary

Official Symbol
Atg6provided by FlyBase
Official Full Name
Autophagy-related 6provided by FlyBase
Primary source
FLYBASE:FBgn0264325
Locus tag
Dmel_CG5429
See related
AllianceGenome:FB:FBgn0264325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
atg6; ATG6; beclin; Beclin-1; Beclin1; BECN1; CG5429; dAtg6; DmAtg6; Dmel\CG5429; l(3)00096
Summary
Enables small GTPase binding activity. Involved in several processes, including glycophagy; larval midgut cell programmed cell death; and neuron remodeling. Part of phosphatidylinositol 3-kinase complex, class III, type I. Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to several human genes including BECN1 (beclin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Atg6 in Genome Data Viewer
Location:
95D10-95D10; 3-82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24049180..24050782, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19874902..19876504, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene Rox8 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylserine decarboxylase Neighboring gene long non-coding RNA:CR44097 Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 68

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase binding  
enables protein-macromolecule adaptor activity  
enables small GTPase binding PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly  
involved_in autophagy  
involved_in autophagy PubMed 
involved_in cellular response to nitrogen starvation  
involved_in cellular response to starvation PubMed 
involved_in defense response to Gram-negative bacterium PubMed 
involved_in endocytosis PubMed 
involved_in glycophagy PubMed 
involved_in hemopoiesis PubMed 
involved_in larval midgut cell programmed cell death PubMed 
involved_in late endosome to vacuole transport  
involved_in macroautophagy PubMed 
involved_in macroautophagy PubMed 
involved_in mitophagy  
involved_in negative regulation of innate immune response PubMed 
involved_in neuron remodeling PubMed 
involved_in protein secretion PubMed 
involved_in response to oxidative stress PubMed 
involved_in response to oxidative stress PubMed 
Component Evidence Code Pubs
is_active_in phagophore assembly site  
part_of phosphatidylinositol 3-kinase complex, class III, type I  
part_of phosphatidylinositol 3-kinase complex, class III, type I PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type II  

General protein information

Preferred Names
Autophagy-related 6
Names
Atg6-PA
Autophagy-specific gene 6
Beclin-1
Beclin1
CG5429-PA
beclin
beclin 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24049180..24050782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142952.3 → NP_651209.1  Autophagy-related 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651209.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCE1
    Related
    FBpp0083975
    Conserved Domains (1) summary
    pfam04111
    Location:110 → 418
    APG6; Autophagy protein Apg6
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