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nAChRalpha1 nicotinic Acetylcholine Receptor alpha1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42918, updated on 4-Jan-2025

Summary

Official Symbol
nAChRalpha1provided by FlyBase
Official Full Name
nicotinic Acetylcholine Receptor alpha1provided by FlyBase
Primary source
FLYBASE:FBgn0000036
Locus tag
Dmel_CG5610
See related
AllianceGenome:FB:FBgn0000036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AChr; AChR; AChRalpha1; Acr96A; Acr96Aa; AcrB; alpha-like; alpha1; als; ALs; ALS; CG5610; CG5610-PA; Dalpha1; Dalpha1 nAChR; dALS; Dmel\CG5610; EMS1; nAChR; nAChR-alpha96Aa; nAChRa1; nAChRalpha-96Aa; nAChRDalpha1; nAcr96Aa; NAcRa96Aa; nAcRalpha-96Aa; nAcRs
Summary
Contributes to acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in cholinergic synaptic transmission; monoatomic cation transmembrane transport; and response to insecticide. Part of acetylcholine-gated channel complex. Is expressed in several structures, including adult head; adult mushroom body; adult optic lobe columnar neurons; brain; and larval central nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See nAChRalpha1 in Genome Data Viewer
Location:
96A1-96A2; 3-85 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24393896..24457157, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20219618..20282879, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43455 Neighboring gene long non-coding RNA:CR45950 Neighboring gene long non-coding RNA:CR45649 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of acetylcholine-gated channel complex  
part_of acetylcholine-gated channel complex PubMed 
part_of acetylcholine-gated channel complex PubMed 
is_active_in neuron projection  
is_active_in plasma membrane  
located_in postsynaptic membrane  
is_active_in synapse  

General protein information

Preferred Names
nicotinic acetylcholine receptor alpha1
Names
ALS
CG5610-PA
CG5610-PB
CG5610-PC
Dalpha1
alpha-like subunit
alpha-like-subunit
nAChRalpha1-PA
nAChRalpha1-PB
nAChRalpha1-PC
nicotinic acetylcholine receptor alpha 96Aa
nicotinic acetylcholine receptor alpha-96Aa
nicotinic acetylcholine receptor alpha-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24393896..24457157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275988.2NP_001262917.1  nicotinic acetylcholine receptor alpha1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262917.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09478, Q9VC74
    UniProtKB/TrEMBL
    A0A0B4KHE6
    Conserved Domains (3) summary
    TIGR00860
    Location:27530
    LIC; Cation transporter family protein
    pfam02931
    Location:25240
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247530
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  2. NM_079757.4NP_524481.2  nicotinic acetylcholine receptor alpha1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524481.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09478, Q9VC74
    UniProtKB/TrEMBL
    A0A0B4KHE6
    Related
    FBpp0084003
    Conserved Domains (3) summary
    TIGR00860
    Location:27530
    LIC; Cation transporter family protein
    pfam02931
    Location:25240
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247530
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. NM_001275987.1NP_001262916.1  nicotinic acetylcholine receptor alpha1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGU3
    Conserved Domains (3) summary
    TIGR00860
    Location:27530
    LIC; Cation transporter family protein
    pfam02931
    Location:25240
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247530
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
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