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CG11089 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42973, updated on 26-Apr-2024

Summary

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Official Symbol
CG11089provided by FlyBase
Primary source
FLYBASE:FBgn0039241
Locus tag
Dmel_CG11089
See related
AllianceGenome:FB:FBgn0039241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
153761_at; atic; BEST:GH11240; CT30991; Dmel\CG11089
Summary
Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in wound healing. Predicted to be active in cytosol. Is expressed in several structures, including early extended germ band embryo; embryonic Malpighian tubule; foregut primordium; gut section; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
96B2-96B2; 3-86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24877045..24881478)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20702767..20707200)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cyclin B3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
  2. Sex-dependent and sex-independent regulatory systems of size variation in natural populations. Okada H, et al. Mol Syst Biol, 2019 Nov. PMID 31777173, Free PMC Article
  3. Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster. Wilinski D, et al. Nat Commun, 2019 Sep 6. PMID 31492856, Free PMC Article
  4. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Tufi R, et al. Nat Cell Biol, 2014 Feb. PMID 24441527, Free PMC Article
  5. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables IMP cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11089-PA
CG11089-PB
NP_001189286.1
NP_651305.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24877045..24881478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143048.2 → NP_651305.1  uncharacterized protein Dmel_CG11089, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651305.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VC18
    Related
    FBpp0084087
    Conserved Domains (3) summary
    PRK07106
    Location:201 → 590
    PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional
    COG0138
    Location:5 → 590
    PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
    cd01421
    Location:5 → 191
    IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...

  2. NM_001202357.1 → NP_001189286.1  uncharacterized protein Dmel_CG11089, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VC18
    Conserved Domains (3) summary
    PRK07106
    Location:201 → 590
    PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional
    COG0138
    Location:5 → 590
    PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
    cd01421
    Location:5 → 191
    IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RT1 Q95RT1
Q9VC18 Q9VC18

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