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amon amontillado [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43215, updated on 4-Jan-2025

Summary

Official Symbol
amonprovided by FlyBase
Official Full Name
amontilladoprovided by FlyBase
Primary source
FLYBASE:FBgn0023179
Locus tag
Dmel_CG6438
See related
AllianceGenome:FB:FBgn0023179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Amon; CG6438; Dmel\CG6438; DMH#5; dPC2; PC2; Ppp; PPP
Summary
Enables peptidase activity. Involved in several processes, including R8 cell fate specification; hatching behavior; and larval wandering behavior. Located in extracellular region. Is expressed in several structures, including adult head; ganglia; gut section; larval CNS neuron; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See amon in Genome Data Viewer
Location:
97C4-97C5; 3-91 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26697697..26714159, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22523419..22539881, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beaten path VII Neighboring gene Tubby Neighboring gene TweedleQ Neighboring gene uncharacterized protein Neighboring gene Yip1-interacting factor 1

Genomic regions, transcripts, and products

Bibliography

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in R8 cell fate specification PubMed 
involved_in carbohydrate homeostasis PubMed 
involved_in hatching behavior PubMed 
involved_in instar larval or pupal development PubMed 
involved_in larval wandering behavior PubMed 
involved_in peptide hormone processing  
involved_in peptide hormone processing PubMed 
involved_in proteolysis PubMed 
involved_in proteolysis  
Component Evidence Code Pubs
located_in extracellular region PubMed 
is_active_in extracellular space  
is_active_in membrane  
is_active_in neuron projection  

General protein information

Preferred Names
amontillado
Names
CG6438-PA
amon-PA
prohormone processing protease
NP_477318.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26697697..26714159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057970.4NP_477318.1  amontillado [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9UAE7, Q9VBC7
    Related
    FBpp0084420
    Conserved Domains (5) summary
    cd04059
    Location:150446
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:187459
    Peptidase_S8; Subtilase family
    pfam01483
    Location:534621
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43122
    S8_pro-domain; Peptidase S8 pro-domain
    cl10459
    Location:409485
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
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