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MMP14 matrix metallopeptidase 14 [ Homo sapiens (human) ]

Gene ID: 4323, updated on 5-Jan-2025

Summary

Official Symbol
MMP14provided by HGNC
Official Full Name
matrix metallopeptidase 14provided by HGNC
Primary source
HGNC:HGNC:7160
See related
Ensembl:ENSG00000157227 MIM:600754; AllianceGenome:HGNC:7160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 130.9), gall bladder (RPKM 96.0) and 20 other tissues See more
Orthologs
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Genomic context

See MMP14 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (22836585..22847758)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17034651..17045822)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23305794..23316967)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23252646-23252816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23283939-23284445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23289156-23289728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5591 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23292150-23292379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23293501-23294397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8144 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23305452-23305668 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23312200-23312700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23312701-23313201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23314693-23315218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23315743-23316266 Neighboring gene Sharpr-MPRA regulatory region 964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5592 Neighboring gene LDL receptor related protein 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23352144-23352682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23352683-23353220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5594 Neighboring gene RRAD and GEM like GTPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Winchester syndrome
MedGen: C0432289 OMIM: 277950 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of matrix metallopeptidase 14 (MMP14) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activity PubMed 
enables integrin binding  
enables metalloaminopeptidase activity PubMed 
enables metalloaminopeptidase activity PubMed 
enables metalloendopeptidase activity  
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity  
enables metalloendopeptidase activity  
enables protein binding PubMed 
enables serine-type endopeptidase activity  
enables zinc ion binding  
Items 1 - 25 of 42
Process Evidence Code Pubs
involved_in angiogenesis  
involved_in astrocyte cell migration  
involved_in branching morphogenesis of an epithelial tube  
involved_in cell motility PubMed 
involved_in chondrocyte proliferation  
involved_in collagen catabolic process  
involved_in collagen catabolic process  
involved_in craniofacial suture morphogenesis  
involved_in embryonic cranial skeleton morphogenesis  
involved_in endochondral ossification  
involved_in endodermal cell differentiation PubMed 
involved_in endothelial cell proliferation  
involved_in extracellular matrix disassembly  
involved_in extracellular matrix organization  
involved_in head development  
involved_in lung development  
involved_in male gonad development  
involved_in negative regulation of GDF15-GFRAL signaling pathway PubMed 
involved_in negative regulation of Notch signaling pathway  
involved_in negative regulation of focal adhesion assembly  
involved_in ovarian follicle development  
involved_in positive regulation of B cell differentiation  
involved_in positive regulation of cell growth PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of macrophage migration  
involved_in positive regulation of myotube differentiation  
involved_in positive regulation of protein processing  
involved_in protein catabolic process PubMed 
involved_in protein processing PubMed 
involved_in proteolysis PubMed 
involved_in proteolysis PubMed 
involved_in regulation of protein localization to plasma membrane PubMed 
involved_in response to estrogen  
involved_in response to hypoxia  
involved_in response to mechanical stimulus  
involved_in response to odorant  
involved_in response to organic cyclic compound  
involved_in response to oxidative stress  
involved_in skeletal system development  
involved_in tissue remodeling  
involved_in zymogen activation  
involved_in zymogen activation PubMed 
Items 1 - 25 of 42
Component Evidence Code Pubs
located_in Golgi lumen  
colocalizes_with cytoplasm PubMed 
located_in cytoplasmic vesicle PubMed 
located_in cytosol  
located_in extracellular matrix  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in focal adhesion PubMed 
located_in intermediate filament cytoskeleton  
located_in macropinosome PubMed 
located_in melanosome  
located_in nucleus PubMed 
is_active_in plasma membrane  
is_active_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
matrix metalloproteinase-14
Names
matrix metallopeptidase 14 (membrane-inserted)
membrane type 1 metalloprotease
membrane-type-1 matrix metalloproteinase
NP_004986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046989.1 RefSeqGene

    Range
    5053..16226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004995.4NP_004986.1  matrix metalloproteinase-14 preproprotein

    See identical proteins and their annotated locations for NP_004986.1

    Status: REVIEWED

    Source sequence(s)
    AL135998, BQ009340, HY075830, Z48481
    Consensus CDS
    CCDS9577.1
    UniProtKB/Swiss-Prot
    A8K5L0, P50281, Q6GSF3, Q92678
    UniProtKB/TrEMBL
    K4RH61
    Related
    ENSP00000308208.6, ENST00000311852.11
    Conserved Domains (5) summary
    cd00094
    Location:316508
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:118284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:118284
    Peptidase_M10; Matrixin
    pfam01471
    Location:3688
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:560582
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    22836585..22847758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17034651..17045822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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