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Fut8 fucosyltransferase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 432392, updated on 2-May-2024

Summary

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Official Symbol
Fut8provided by RGD
Official Full Name
fucosyltransferase 8provided by RGD
Primary source
RGD:1303096
See related
Ensembl:ENSRNOG00000008451 AllianceGenome:RGD:1303096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glycoprotein 6-alpha-L-fucosyltransferase activity. Predicted to be involved in GDP-L-fucose metabolic process; N-glycan fucosylation; and protein N-linked glycosylation via asparagine. Predicted to act upstream of or within several processes, including N-glycan processing; cell surface receptor signaling pathway; and regulation of cellular response to oxidative stress. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 118.8), Kidney (RPKM 102.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101682354..101909784)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95949246..96176677)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (100305957..100537208)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479401 Neighboring gene small nucleolar RNA, H/ACA box 50D Neighboring gene ankyrin repeat domain-containing protein 49-like Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120103557

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0. Teylaert B, et al. BMC Biotechnol, 2011 Jan 5. PMID 21208406, Free PMC Article
  2. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. Ihara H, et al. Glycobiology, 2007 May. PMID 17172260
  3. Molecular cloning of mouse alpha-1,6-fucosyltransferase and expression of its mRNA in the developing cerebrum. Hayashi H, et al. DNA Seq, 2000. PMID 10902914
  4. Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions. Zhao Y, et al. J Biol Chem, 2006 Dec 15. PMID 17043354
  5. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cDNAs encoding the rat alpha1,6-fucosyltransferase (FucT VIII) were cloned from YB2/0 cells by polymerase chain reaction-based and 5' RNA-Ligase-Mediated RACE methods.
    Title: Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-(1->6)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->6)-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycoprotein 6-alpha-L-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycoprotein 6-alpha-L-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycoprotein 6-alpha-L-fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GDP-L-fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-L-fucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GDP-L-fucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in N-glycan fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan fucosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within N-glycan fucosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in N-glycan processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within receptor metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in respiratory gaseous exchange by respiratory system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-(1,6)-fucosyltransferase
Names
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
alpha1-6FucT
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
glycoprotein 6-alpha-L-fucosyltransferase
NP_001002289.2
NP_001399118.1
XP_038968588.1
XP_063118317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002289.2 → NP_001002289.2  alpha-(1,6)-fucosyltransferase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HCC9, D4IGX4, D4IGX5
    Related
    ENSRNOP00000089026.1, ENSRNOT00000096219.1

  2. NM_001412189.1 → NP_001399118.1  alpha-(1,6)-fucosyltransferase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HCC9, D4IGX4, D4IGX5
    Related
    ENSRNOP00000011220.2, ENSRNOT00000011220.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    101682354..101909784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112660.2 → XP_038968588.1  alpha-(1,6)-fucosyltransferase isoform X2

    UniProtKB/Swiss-Prot
    Q6EV76
    Conserved Domains (2) summary
    cd11300
    Location:208 → 533
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:540 → 594
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

  2. XM_063262247.1 → XP_063118317.1  alpha-(1,6)-fucosyltransferase isoform X1

    UniProtKB/TrEMBL
    A6HCC9, D4IGX4, D4IGX5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6EV76.1 GenPept UniProtKB/Swiss-Prot:Q6EV76

Gene LinkOut

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