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Nom1 nucleolar protein with MIF4G domain 1 [ Mus musculus (house mouse) ]

Gene ID: 433864, updated on 12-May-2024

Summary

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Official Symbol
Nom1provided by MGI
Official Full Name
nucleolar protein with MIF4G domain 1provided by MGI
Primary source
MGI:MGI:1861749
See related
Ensembl:ENSMUSG00000001569 AllianceGenome:MGI:1861749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Kng1; Gm1040
Summary
Predicted to enable RNA binding activity. Acts upstream of or within hair follicle maturation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including bladder; dorsal root ganglion; limb; skeleton; and ventral grey horn. Orthologous to human NOM1 (nucleolar protein with MIF4G domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.8), liver E14 (RPKM 6.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nom1 in Genome Data Viewer
Location:
5 B1; 5 15.0 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (29637338..29658504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (29434659..29452169)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene limb region 1 Neighboring gene STARR-seq mESC enhancer starr_12732 Neighboring gene STARR-seq mESC enhancer starr_12733 Neighboring gene zone of polarising activity regulatory sequence 1 Neighboring gene STARR-seq mESC enhancer starr_12734 Neighboring gene STARR-positive B cell enhancer ABC_E9634 Neighboring gene predicted gene, 36086 Neighboring gene STARR-positive B cell enhancer ABC_E9252 Neighboring gene predicted gene, 24538 Neighboring gene motor neuron and pancreas homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Symmons O, et al. Dev Cell, 2016 Dec 5. PMID 27867070, Free PMC Article
  2. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Amano T, et al. Dev Cell, 2009 Jan. PMID 19097946
  3. Mapping the Shh long-range regulatory domain. Anderson E, et al. Development, 2014 Oct. PMID 25252942, Free PMC Article
  4. A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice. Clark RM, et al. Genomics, 2000 Jul 1. PMID 10945466
  5. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleolar MIF4G domain-containing protein 1
Names
SGD1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033457.2 → NP_001028629.2  nucleolar MIF4G domain-containing protein 1

    See identical proteins and their annotated locations for NP_001028629.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    AC171500, AK148406
    Consensus CDS
    CCDS19149.1
    UniProtKB/Swiss-Prot
    E9QPB9, Q3UFM5
    Related
    ENSMUSP00000001611.10, ENSMUST00000001611.11
    Conserved Domains (2) summary
    smart00543
    Location:357 → 553
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    cl02653
    Location:649 → 755
    MA3; MA3 domain

RNA

  1. NR_153385.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' exon and contains another alternate 3' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC171500

  2. NR_153386.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC171500

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    29637338..29658504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535742.4 → XP_006535805.1  nucleolar MIF4G domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    smart00543
    Location:357 → 553
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam07263
    Location:255 → 332
    DMP1; Dentin matrix protein 1 (DMP1)
    cl02653
    Location:649 → 755
    MA3; MA3 domain

  2. XM_011249776.3 → XP_011248078.1  nucleolar MIF4G domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    smart00543
    Location:357 → 553
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam07263
    Location:255 → 332
    DMP1; Dentin matrix protein 1 (DMP1)
    cl02653
    Location:649 → 755
    MA3; MA3 domain

RNA

  1. XR_001784716.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UFM5.2 GenPept UniProtKB/Swiss-Prot:Q3UFM5

Gene LinkOut

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