beta4GalNAcTB beta1,4-N-acetylgalactosaminyltransferase B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: beta4GalNAcTBprovided by FlyBase
Official Full Name: beta1,4-N-acetylgalactosaminyltransferase Bprovided by FlyBase
Primary source: FLYBASE:FBgn0039625
Locus tag: Dmel_CG14517
See related: AllianceGenome:FB:FBgn0039625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta4GalNacTB; beta4GalTB; betaGalNAcTB; CG14517; dbeta4GalTB; Dmel\CG14517
Summary: Enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity and beta-1,4-N-acetylgalactosaminyltransferase activity. Involved in N-acetylglucosamine metabolic process and glycosphingolipid biosynthetic process. Located in Golgi apparatus. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to several human genes including B4GALT1 (beta-1,4-galactosyltransferase 1); B4GALT2 (beta-1,4-galactosyltransferase 2); and B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29032660..29034008, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24858382..24859730, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Lumenal loop regions are insect-conserved and essential for GABPI-b4GalNAcTB interaction.
Title: "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.
GABPI is required for ER export and activity of beta4GalNAcTB. [GABPI]
Title: Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

NP_651657.1

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The following sections contain reference sequences that belong to a specific genome build. Explain