alpha-Man-Ib alpha-Mannosidase class I b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alpha-Man-Ibprovided by FlyBase
Official Full Name: alpha-Mannosidase class I bprovided by FlyBase
Primary source: FLYBASE:FBgn0039634
Locus tag: Dmel_CG11874
See related: AllianceGenome:FB:FBgn0039634
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11874; dMas-3; Dmel\CG11874; mas-3; ORE-11
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in encapsulation of foreign target. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic brain; embryonic/larval nervous system; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29109053..29112822, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24934775..24938544, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose trimming involved in glycoprotein ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_651667.1

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The following sections contain reference sequences that belong to a specific genome build. Explain