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Tace tace [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43558, updated on 4-Jan-2025

Summary

Official Symbol
Taceprovided by FlyBase
Official Full Name
taceprovided by FlyBase
Primary source
FLYBASE:FBgn0039734
Locus tag
Dmel_CG7908
See related
AllianceGenome:FB:FBgn0039734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADAM17; CG7908; CT23908; Dmel\CG7908; DTACE; tace; TACE; TNF-alpha converting enzyme
Summary
Enables metalloendopeptidase activity. Involved in several processes, including cell surface receptor signaling pathway; commissural neuron axon guidance; and membrane protein ectodomain proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Tace in Genome Data Viewer
Location:
99D1-99D1; 3-100 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30000530..30003678)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25826252..25829400)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nucleophosmin Neighboring gene Nucleoplasmin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity  
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity  
enables metalloendopeptidase activity PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing PubMed 
involved_in Notch signaling pathway  
involved_in Notch signaling pathway PubMed 
involved_in commissural neuron axon guidance PubMed 
involved_in membrane protein ectodomain proteolysis  
involved_in membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis  
involved_in negative regulation of multicellular organism growth PubMed 
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process PubMed 
acts_upstream_of positive regulation of programmed cell death PubMed 
involved_in proteolysis  
involved_in tumor necrosis factor-mediated signaling pathway PubMed 
involved_in tumor necrosis factor-mediated signaling pathway PubMed 
involved_in tumor necrosis factor-mediated signaling pathway PubMed 
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  

General protein information

Preferred Names
tace
Names
CG7908-PA
CG7908-PB
Tace-PA
Tace-PB
tumor necrosis factor-alpha-converting enzyme
NP_651759.4
NP_733334.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30000530..30003678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143502.4 → NP_651759.4  tace, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651759.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R7M1
    Conserved Domains (2) summary
    pfam01562
    Location:50 → 162
    Pep_M12B_propep; Reprolysin family propeptide
    cl00064
    Location:223 → 256
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. NM_170455.3 → NP_733334.1  tace, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733334.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q868A7, Q8IMJ9, Q95RZ4, Q9VAC5
    Related
    FBpp0084917
    Conserved Domains (5) summary
    cd04270
    Location:223 → 470
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    cd14246
    Location:576 → 633
    ADAM17_MPD; Membrane-proximal domain of a disintegrin and metalloprotease 17 (ADAM17)
    pfam00200
    Location:477 → 552
    Disintegrin; Disintegrin
    pfam01562
    Location:50 → 162
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:244 → 456
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
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