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b4galt7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) [ Danio rerio (zebrafish) ]

Gene ID: 445022, updated on 27-Mar-2024

Summary

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Official Symbol
b4galt7provided by ZNC
Official Full Name
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040727-3
See related
Ensembl:ENSDARG00000021899 AllianceGenome:ZFIN:ZDB-GENE-040727-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110571
Summary
Predicted to enable xylosylprotein 4-beta-galactosyltransferase activity. Predicted to be involved in glycosylation and proteoglycan biosynthetic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (26380451..26392198, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (26083847..26094035, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 69 Neighboring gene empty spiracles homeobox 3 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 212 Neighboring gene transmembrane p24 trafficking protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome. Delbaere S, et al. Matrix Biol, 2020 Jul. PMID 31862401
  2. Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos. Naert T, et al. Sci Rep, 2020 Sep 4. PMID 32887910, Free PMC Article
  3. b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region. Delbaere S, et al. Front Cell Dev Biol, 2020. PMID 33363150, Free PMC Article
  4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypomorphic zebrafish models mimic the musculoskeletal phenotype of beta4GalT7-deficient Ehlers-Danlos syndrome.
    Title: Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC110571

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables xylosylprotein 4-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hatching behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thigmotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 7
NP_001003417.1
XP_021336677.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003417.1 → NP_001003417.1  beta-1,4-galactosyltransferase 7

    See identical proteins and their annotated locations for NP_001003417.1

    Status: PROVISIONAL

    Source sequence(s)
    AY648740
    UniProtKB/TrEMBL
    Q6DRL9
    Related
    ENSDARP00000030294.4, ENSDART00000037999.5
    Conserved Domains (1) summary
    cd00899
    Location:82 → 305
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    26380451..26392198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481002.1 → XP_021336677.1  beta-1,4-galactosyltransferase 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PZ57
    Related
    ENSDARP00000131716.1, ENSDART00000170614.2
    Conserved Domains (1) summary
    cd00899
    Location:93 → 316
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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