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Ufc1 ubiquitin-fold modifier conjugating enzyme 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 445268, updated on 3-May-2024

Summary

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Official Symbol
Ufc1provided by RGD
Official Full Name
ubiquitin-fold modifier conjugating enzyme 1provided by RGD
Primary source
RGD:1303313
See related
Ensembl:ENSRNOG00000003706 AllianceGenome:RGD:1303313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ufc1-s
Summary
Predicted to enable UFM1 conjugating enzyme activity. Predicted to be involved in several processes, including protein K69-linked ufmylation; response to endoplasmic reticulum stress; and reticulophagy. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 488.4), Liver (RPKM 461.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ufc1 in Genome Data Viewer
Location:
13q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86241779..86280513, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83709329..83719762, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89661763..89668513, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin specific peptidase 21 Neighboring gene G protein subunit gamma 5, pseudogene 1 Neighboring gene death effector domain-containing Neighboring gene nitrilase 1 Neighboring gene prefoldin subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development. Nahorski MS, et al. Brain, 2018 Jul 1. PMID 29868776, Free PMC Article
  2. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. Komatsu M, et al. EMBO J, 2004 May 5. PMID 15071506, Free PMC Article
  3. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Yoo HM, et al. Mol Cell, 2014 Oct 23. PMID 25219498
  4. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. Zhang Y, et al. PLoS One, 2012. PMID 23152784, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105791

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UFM1 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables UFM1 conjugating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables UFM1 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K69-linked ufmylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ufmylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ufmylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ufmylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in reticulophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in reticulophagy ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ubiquitin-fold modifier-conjugating enzyme 1
Names
Ufm1-conjugating enzyme 1-
ufm1-conjugating enzyme 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003709.3 → NP_001003709.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 1

    See identical proteins and their annotated locations for NP_001003709.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q6BBI8
    UniProtKB/TrEMBL
    A6JFW9
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

  2. NM_001429935.1 → NP_001416864.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001429936.1 → NP_001416865.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  4. NM_001429937.1 → NP_001416866.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    86241779..86280513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090960.2 → XP_038946888.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6BBI8
    UniProtKB/TrEMBL
    A6JFW9
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

  2. XM_063272529.1 → XP_063128599.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6BBI8
    UniProtKB/TrEMBL
    A6JFW9

  3. XM_006250251.4 → XP_006250313.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6BBI8
    UniProtKB/TrEMBL
    A6JFW9
    Related
    ENSRNOP00000004938.3
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6BBI8.1 GenPept UniProtKB/Swiss-Prot:Q6BBI8

Gene LinkOut

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