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pon1 paraoxonase 1 [ Danio rerio (zebrafish) ]

Gene ID: 447803, updated on 4-Jan-2025

Summary

Official Symbol
pon1provided by ZNC
Official Full Name
paraoxonase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040912-6
See related
Ensembl:ENSDARG00000032496 AllianceGenome:ZFIN:ZDB-GENE-040912-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91887
Summary
Predicted to enable arylesterase activity and metal ion binding activity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); dementia (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1); PON2 (paraoxonase 2); and PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See pon1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (24646600..24656265, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24731568..24741233, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene FXYD domain containing ion transport regulator 7 Neighboring gene FXYD domain containing ion transport regulator 6 like Neighboring gene si:dkey-56f14.7 Neighboring gene paraoxonase 3, tandem duplicate 2 Neighboring gene paraoxonase 3, tandem duplicate 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables arylesterase activity  
enables hydrolase activity  
enables metal ion binding  
Component Evidence Code Pubs
is_active_in cellular_component  

General protein information

Preferred Names
serum paraoxonase/arylesterase 1
NP_001004542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004542.1NP_001004542.1  serum paraoxonase/arylesterase 1

    See identical proteins and their annotated locations for NP_001004542.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080844
    UniProtKB/TrEMBL
    B2GQ34, F6NHB4, Q66JN5
    Related
    ENSDARP00000015826.8, ENSDART00000019353.9
    Conserved Domains (2) summary
    COG3386
    Location:111297
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cl22863
    Location:168253
    Str_synth; Strictosidine synthase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    24646600..24656265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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