MT1JP metallothionein 1J, pseudogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT1JPprovided by HGNC
Official Full Name: metallothionein 1J, pseudogeneprovided by HGNC
Primary source: HGNC:HGNC:7402
See related: Ensembl:ENSG00000290662 MIM:156356; AllianceGenome:HGNC:7402
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT1; MTB; MT1J; MT1NP
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56635739..56637086)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62430718..62432065)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56669651..56670998)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1alpha (HIF-1alpha).
Title: Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1α (HIF-1α).
MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.
Title: MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis.
LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis.
Title: LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis.
Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma.
Title: Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma.
MT1JP, miRNA-423-3p, and Bim expressions in NSCLC cancer tissues and those in adjacent cancer tissues were significantly different (<i>P</i><0.01 or <i>P</i><0.001) with increasing stage.
Title: Long-Chain Non-Coding RNA (lncRNA) MT1JP Suppresses Biological Activities of Lung Cancer by Regulating miRNA-423-3p/Bim Axis.
Study results revealed that LncRNA MT1JP was down-regulated, while beta-catenin was highly expressed in retinoblastoma cells. Forced expression of MT1JP impaired the expression of the beta-catenin protein and its downstream targets such as cyclin D1, c-myc suggesting that MT1JP acting as a tumor suppressor in the development of retinoblastoma and might function as a prognostic biomarker.
Title: LncRNA MT1JP acts as a tumor inhibitor via reciprocally regulating Wnt/β-Catenin pathway in retinoblastoma.
LncRNA MT1JP was significantly lower in gastric cancer (GC) tissues than adjacent normal tissues, and higher MT1JP was remarkably related to lymph node metastasis and advance stage. lncRNA MT1JP acted as a competing endogenous RNA in regulating FBXW7 through sponging miR-92a-3p and inhibit cell proliferation, migration, invasion and promote cell apoptosis.
Title: LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer.
we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR
Title: LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

metallothionein 1M pseudogene
metallothionein 1N, pseudogene
metallothionein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_036677.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AF348994

Related

ENST00000563395.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

56635739..56637086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

62430718..62432065

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_005506.2: Suppressed sequence

Description

NG_005506.2: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
NM_175622.3: Suppressed sequence

Description

NM_175622.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.