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MT1X metallothionein 1X [ Homo sapiens (human) ]

Gene ID: 4501, updated on 4-Jan-2025

Summary

Official Symbol
MT1Xprovided by HGNC
Official Full Name
metallothionein 1Xprovided by HGNC
Primary source
HGNC:HGNC:7405
See related
Ensembl:ENSG00000187193 MIM:156359; AllianceGenome:HGNC:7405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1; MT-1l
Summary
Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in cellular response to cadmium ion; cellular response to erythropoietin; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in liver (RPKM 301.6), kidney (RPKM 245.8) and 16 other tissues See more
Orthologs
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Genomic context

See MT1X in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56682470..56684196)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62477453..62479178)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56716382..56718108)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:56708581-56709252 Neighboring gene metallothionein 1H Neighboring gene metallothionein 1I, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:56716235-56716766 Neighboring gene developmental pluripotency associated 2 pseudogene 4 Neighboring gene uncharacterized LOC105371287 Neighboring gene NUP93 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of metallothionein 1X (MT1X) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding  
enables protein binding PubMed 
enables zinc ion binding  
Process Evidence Code Pubs
involved_in cellular response to cadmium ion  
involved_in cellular response to cadmium ion PubMed 
involved_in cellular response to copper ion  
involved_in cellular response to erythropoietin PubMed 
involved_in cellular response to zinc ion  
involved_in cellular response to zinc ion PubMed 
involved_in detoxification of copper ion  
involved_in intracellular zinc ion homeostasis  
involved_in negative regulation of growth  
involved_in response to metal ion PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
metallothionein-1X
Names
MT-1X
MT-IX
metallothionein-IX
testicular tissue protein Li 124

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005952.4NP_005943.1  metallothionein-1X

    See identical proteins and their annotated locations for NP_005943.1

    Status: VALIDATED

    Source sequence(s)
    BC032338, CD101947
    Consensus CDS
    CCDS10768.1
    UniProtKB/Swiss-Prot
    A8MUC7, P80297
    UniProtKB/TrEMBL
    A0A140VJP8
    Related
    ENSP00000377995.4, ENST00000394485.5
    Conserved Domains (1) summary
    pfam00131
    Location:161
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    56682470..56684196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62477453..62479178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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