MTA2 metastasis associated 1 family member 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MTA2provided by VGNC
Official Full Name: metastasis associated 1 family member 2provided by VGNC
Primary source: VGNC:VGNC:43457
See related: Ensembl:ENSCAFG00845009498
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (55090555..55098627)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (52643059..52651411)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (54557159..54565475)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (54186653..54194966)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (53761506..53769853)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

MARC_4683-4684:996679606:1 (e-PCR)
- UniSTS:269418

MARC_15747-15748:1017934441:1 (e-PCR)
- UniSTS:267891

ksks80 (e-PCR)
- UniSTS:514548

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metastasis-associated protein MTA2; LOW QUALITY PROTEIN: metastasis-associated protein MTA2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051822.1 Reference ROS_Cfam_1.0

Range

55090555..55098627

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038425331.1 → XP_038281259.1 metastasis-associated protein MTA2 isoform X1

UniProtKB/TrEMBL

A0A8C0KIP0, A0A8C0M8T3, A0A8I3N2N1, A0A8P0NH31

Related

ENSCAFP00845013032.1, ENSCAFT00845016756.1

Conserved Domains (5) summary

cd11661
Location:267 → 312

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:363 → 413

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 168

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:147 → 198

ELM2; ELM2 domain

pfam17226
Location:449 → 524

MTA_R1; MTA R1 domain
XM_038425332.1 → XP_038281260.1 metastasis-associated protein MTA2 isoform X2

UniProtKB/TrEMBL

A0A8C0KGT9, A0A8C0M8T3

Conserved Domains (5) summary

cd11661
Location:261 → 306

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:357 → 407

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:4 → 162

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:141 → 192

ELM2; ELM2 domain

pfam17226
Location:443 → 518

MTA_R1; MTA R1 domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049278.1 Alternate UMICH_Zoey_3.1

Range

54186653..54194966

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038501598.1 → XP_038357526.1 LOW QUALITY PROTEIN: metastasis-associated protein MTA2 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049759.1 Alternate UNSW_CanFamBas_1.0

Range

53761506..53769853

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038628423.1 → XP_038484351.1 metastasis-associated protein MTA2 isoform X1

Conserved Domains (5) summary

cd11661
Location:267 → 312

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:363 → 413

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 168

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:147 → 198

ELM2; ELM2 domain

pfam17226
Location:449 → 524

MTA_R1; MTA R1 domain
XM_038628424.1 → XP_038484352.1 metastasis-associated protein MTA2 isoform X2

Conserved Domains (5) summary

cd11661
Location:261 → 306

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:357 → 407

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:4 → 162

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:141 → 192

ELM2; ELM2 domain

pfam17226
Location:443 → 518

MTA_R1; MTA R1 domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049239.1 Alternate UU_Cfam_GSD_1.0

Range

54557159..54565475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038564288.1 → XP_038420216.1 metastasis-associated protein MTA2 isoform X1

UniProtKB/TrEMBL

A0A8C0KIP0, A0A8C0M8T3, A0A8I3N2N1, A0A8P0NH31

Conserved Domains (5) summary

cd11661
Location:267 → 312

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:363 → 413

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 168

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:147 → 198

ELM2; ELM2 domain

pfam17226
Location:449 → 524

MTA_R1; MTA R1 domain
XM_038564289.1 → XP_038420217.1 metastasis-associated protein MTA2 isoform X2

UniProtKB/TrEMBL

A0A8C0KGT9, A0A8C0M8T3

Conserved Domains (5) summary

cd11661
Location:261 → 306

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:357 → 407

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:4 → 162

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:141 → 192

ELM2; ELM2 domain

pfam17226
Location:443 → 518

MTA_R1; MTA R1 domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

52643059..52651411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_533265.7 → XP_533265.2 metastasis-associated protein MTA2 isoform X1

UniProtKB/TrEMBL

A0A8C0KIP0, A0A8C0M8T3, A0A8I3N2N1, A0A8P0NH31

Conserved Domains (5) summary

cd11661
Location:267 → 312

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:363 → 413

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 168

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:147 → 198

ELM2; ELM2 domain

pfam17226
Location:449 → 524

MTA_R1; MTA R1 domain
XM_005631620.4 → XP_005631677.1 metastasis-associated protein MTA2 isoform X2

UniProtKB/TrEMBL

A0A8C0KGT9, A0A8C0M8T3

Conserved Domains (5) summary

cd11661
Location:261 → 306

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:357 → 407

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:4 → 162

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:141 → 192

ELM2; ELM2 domain

pfam17226
Location:443 → 518

MTA_R1; MTA R1 domain