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TLE1 TLE family member 1, transcriptional corepressor [ Canis lupus familiaris (dog) ]

Gene ID: 476314, updated on 5-Mar-2024

Summary

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Official Symbol
TLE1provided by VGNC
Official Full Name
TLE family member 1, transcriptional corepressorprovided by VGNC
Primary source
VGNC:VGNC:47396
See related
Ensembl:ENSCAFG00845007046
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human all
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Genomic context

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Location:
chromosome: 1
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (77890529..77976812)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (78176439..78262403)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (78174199..78260171)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (77728749..77814641)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (77457041..77542974)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis-associated protein 31D4-like Neighboring gene spermatogenesis-associated protein 31D3-like Neighboring gene uncharacterized LOC119870826 Neighboring gene uncharacterized LOC111096585 Neighboring gene uncharacterized LOC111096586

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transducin-like enhancer protein 1
Names
transducin like enhancer of split 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    77890529..77976812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038655122.1 → XP_038511050.1  transducin-like enhancer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M3D4, A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:329 → 486
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:493 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_038655123.1 → XP_038511051.1  transducin-like enhancer protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:328 → 485
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:492 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  3. XM_038655124.1 → XP_038511052.1  transducin-like enhancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LIQ0, A0A8C0M9E3, A0A8C0RVI5, A0A8I3N1N3
    Related
    ENSCAFP00845009776.1, ENSCAFT00845012514.1
    Conserved Domains (4) summary
    PHA03247
    Location:319 → 476
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:483 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  4. XM_038655125.1 → XP_038511053.1  transducin-like enhancer protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:318 → 475
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. XM_038655126.1 → XP_038511054.1  transducin-like enhancer protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RBV8, A0A8I3RTS8
    Conserved Domains (4) summary
    PHA03247
    Location:245 → 402
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:409 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:413 → 452
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. XM_038655127.1 → XP_038511055.1  transducin-like enhancer protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0RBV8, A0A8I3RTS8
    Conserved Domains (3) summary
    PHA03247
    Location:214 → 371
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:378 → 662
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:382 → 421
    7WD40; WD40 repeat [structural motif]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    77728749..77814641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038466315.1 → XP_038322243.1  transducin-like enhancer protein 1 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:329 → 486
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:493 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_038466316.1 → XP_038322244.1  transducin-like enhancer protein 1 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:328 → 485
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:492 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  3. XM_038466317.1 → XP_038322245.1  transducin-like enhancer protein 1 isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:319 → 476
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:483 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  4. XM_038466318.1 → XP_038322246.1  transducin-like enhancer protein 1 isoform X4

    Conserved Domains (4) summary
    PHA03247
    Location:318 → 475
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. XM_038466319.1 → XP_038322247.1  transducin-like enhancer protein 1 isoform X5

    Conserved Domains (4) summary
    PHA03247
    Location:245 → 402
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:409 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:413 → 452
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. XM_038466320.1 → XP_038322248.1  transducin-like enhancer protein 1 isoform X6

    Conserved Domains (3) summary
    PHA03247
    Location:214 → 371
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:378 → 662
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:382 → 421
    7WD40; WD40 repeat [structural motif]

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    77457041..77542974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038591314.1 → XP_038447242.1  transducin-like enhancer protein 1 isoform X1

  2. XM_038591315.1 → XP_038447243.1  transducin-like enhancer protein 1 isoform X2

  3. XM_038591316.1 → XP_038447244.1  transducin-like enhancer protein 1 isoform X3

  4. XM_038591317.1 → XP_038447245.1  transducin-like enhancer protein 1 isoform X4

  5. XM_038591318.1 → XP_038447246.1  transducin-like enhancer protein 1 isoform X5

  6. XM_038591319.1 → XP_038447247.1  transducin-like enhancer protein 1 isoform X6

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    78174199..78260171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038527009.1 → XP_038382937.1  transducin-like enhancer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M3D4, A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:329 → 486
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:493 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_038527010.1 → XP_038382938.1  transducin-like enhancer protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:328 → 485
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:492 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  3. XM_038527011.1 → XP_038382939.1  transducin-like enhancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LIQ0, A0A8C0M9E3, A0A8C0RVI5, A0A8I3N1N3
    Conserved Domains (4) summary
    PHA03247
    Location:319 → 476
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:483 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  4. XM_038527012.1 → XP_038382940.1  transducin-like enhancer protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:318 → 475
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. XM_038527013.1 → XP_038382941.1  transducin-like enhancer protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RBV8, A0A8I3RTS8
    Conserved Domains (4) summary
    PHA03247
    Location:245 → 402
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:409 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:413 → 452
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. XM_038527014.1 → XP_038382942.1  transducin-like enhancer protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0RBV8, A0A8I3RTS8
    Conserved Domains (3) summary
    PHA03247
    Location:214 → 371
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:378 → 662
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:382 → 421
    7WD40; WD40 repeat [structural motif]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    78176439..78262403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577256.1 → XP_038433184.1  transducin-like enhancer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0M3D4, A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:329 → 486
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:493 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_038577346.1 → XP_038433274.1  transducin-like enhancer protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:328 → 485
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:492 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  3. XM_038577423.1 → XP_038433351.1  transducin-like enhancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LIQ0, A0A8C0M9E3, A0A8C0RVI5, A0A8I3N1N3
    Conserved Domains (4) summary
    PHA03247
    Location:319 → 476
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:483 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  4. XM_038577492.1 → XP_038433420.1  transducin-like enhancer protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0M9E3
    Conserved Domains (4) summary
    PHA03247
    Location:318 → 475
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. XM_038577578.1 → XP_038433506.1  transducin-like enhancer protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0RBV8, A0A8I3RTS8
    Conserved Domains (4) summary
    PHA03247
    Location:245 → 402
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:409 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:413 → 452
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. XM_038577655.1 → XP_038433583.1  transducin-like enhancer protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8C0RBV8, A0A8I3RTS8
    Conserved Domains (3) summary
    PHA03247
    Location:214 → 371
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:378 → 662
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:382 → 421
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
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