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MAPK8 mitogen-activated protein kinase 8 [ Canis lupus familiaris (dog) ]

Gene ID: 477746, updated on 5-Mar-2024

Summary

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Official Symbol
MAPK8provided by VGNC
Official Full Name
mitogen-activated protein kinase 8provided by VGNC
Primary source
VGNC:VGNC:43001
See related
Ensembl:ENSCAFG00845019380
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (498642..586320)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (552432..639965)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (432766..552601)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (298436..386002)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (339385..427241)

Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 20 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene Rho GTPase activating protein 22 Neighboring gene uncharacterized LOC102152118 Neighboring gene uncharacterized LOC111093070 Neighboring gene WDFY family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ERK2 and JNK1 contribute to TNF-α-induced IL-8 expression in synovial fibroblasts. Namba S, et al. PLoS One, 2017. PMID 28806729, Free PMC Article
  2. Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha. Yanamadala V, et al. J Biol Chem, 2007 Aug 17. PMID 17565996

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 8
XP_005637524.1
XP_013964376.1
XP_022267801.1
XP_038295667.1
XP_038295668.1
XP_038295669.1
XP_038295670.1
XP_038295671.1
XP_038295672.1
XP_038295673.1
XP_038295674.1
XP_038316263.1
XP_038316264.1
XP_038316266.1
XP_038370289.1
XP_038370290.1
XP_038370291.1
XP_038370292.1
XP_038370293.1
XP_038370294.1
XP_038370295.1
XP_038370296.1
XP_038433941.1
XP_038433942.1
XP_038433943.1
XP_038433944.1
XP_038433945.1
XP_038433946.1
XP_038433947.1
XP_038433948.1
XP_038498101.1
XP_038498102.1
XP_038498103.1
XP_038498104.1
XP_038498106.1
XP_038498107.1
XP_038498108.1
XP_038498109.1
XP_534943.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051832.1 Reference ROS_Cfam_1.0

    Range
    498642..586320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038439740.1 → XP_038295668.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_038439745.1 → XP_038295673.1  mitogen-activated protein kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038439741.1 → XP_038295669.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_038439742.1 → XP_038295670.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_038439743.1 → XP_038295671.1  mitogen-activated protein kinase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8P0SEG5
    Related
    ENSCAFP00845027030.1, ENSCAFT00845034508.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_038439746.1 → XP_038295674.1  mitogen-activated protein kinase 8 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KBA7, A0A8C0R7K1, A0A8C0T9H7
    Conserved Domains (1) summary
    cl21453
    Location:25 → 205
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038439739.1 → XP_038295667.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_038439744.1 → XP_038295672.1  mitogen-activated protein kinase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8I3NY64, A0A8I3P9R9
    Related
    ENSCAFP00845026947.1, ENSCAFT00845034410.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. XR_005303474.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049288.1 Alternate UMICH_Zoey_3.1

    Range
    298436..386002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038514362.1 → XP_038370290.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_038514367.1 → XP_038370295.1  mitogen-activated protein kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038514363.1 → XP_038370291.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_038514364.1 → XP_038370292.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_038514365.1 → XP_038370293.1  mitogen-activated protein kinase 8 isoform X2

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_038514368.1 → XP_038370296.1  mitogen-activated protein kinase 8 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:25 → 205
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038514361.1 → XP_038370289.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_038514366.1 → XP_038370294.1  mitogen-activated protein kinase 8 isoform X3

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. XR_005346569.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

    Range
    339385..427241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038642174.1 → XP_038498102.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_038642180.1 → XP_038498108.1  mitogen-activated protein kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038642175.1 → XP_038498103.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_038642176.1 → XP_038498104.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_038642178.1 → XP_038498106.1  mitogen-activated protein kinase 8 isoform X2

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_038642181.1 → XP_038498109.1  mitogen-activated protein kinase 8 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:25 → 205
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038642173.1 → XP_038498101.1  mitogen-activated protein kinase 8 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_038642179.1 → XP_038498107.1  mitogen-activated protein kinase 8 isoform X3

    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. XR_005414088.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

    Range
    432766..552601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038578014.1 → XP_038433942.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_038578019.1 → XP_038433947.1  mitogen-activated protein kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038578015.1 → XP_038433943.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_038578016.1 → XP_038433944.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_038578017.1 → XP_038433945.1  mitogen-activated protein kinase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NVS4, A0A8P0SEG5
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_038578020.1 → XP_038433948.1  mitogen-activated protein kinase 8 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KBA7, A0A8C0R7K1, A0A8C0T9H7
    Conserved Domains (1) summary
    cl21453
    Location:25 → 205
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038578013.1 → XP_038433941.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_038578018.1 → XP_038433946.1  mitogen-activated protein kinase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R7H4, A0A8C0TF14, A0A8I3NY64, A0A8P0N8Z6
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. XR_005380344.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    552432..639965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460335.1 → XP_038316263.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_038460338.1 → XP_038316266.1  mitogen-activated protein kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038460336.1 → XP_038316264.1  mitogen-activated protein kinase 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_534943.7 → XP_534943.2  mitogen-activated protein kinase 8 isoform X2

    See identical proteins and their annotated locations for XP_534943.2

    UniProtKB/TrEMBL
    A0A8C0NVS4, A0A8P0SEG5
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_005637467.4 → XP_005637524.1  mitogen-activated protein kinase 8 isoform X1

    See identical proteins and their annotated locations for XP_005637524.1

    UniProtKB/TrEMBL
    A0A8C0NSG4, A0A8I3PQ77
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_022412093.2 → XP_022267801.1  mitogen-activated protein kinase 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R7H4, A0A8C0TF14, A0A8I3NY64, A0A8P0N8Z6
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. XM_014108901.3 → XP_013964376.1  mitogen-activated protein kinase 8 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KBA7, A0A8C0R7K1, A0A8C0T9H7
    Conserved Domains (1) summary
    cl21453
    Location:25 → 205
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_002620745.2 RNA Sequence

Nucleotide Protein
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