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Act87E Actin 87E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48632, updated on 10-May-2024

Summary

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Official Symbol
Act87Eprovided by FlyBase
Official Full Name
Actin 87Eprovided by FlyBase
Primary source
FLYBASE:FBgn0000046
Locus tag
Dmel_CG18290
See related
AllianceGenome:FB:FBgn0000046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
act 87E; ACT5; act87E; Act87e; actin; Actin; actin-87E; Actin87E; ArpC; CG18290; Dmel\CG18290; E; mus87E
Summary
Involved in histone acetylation and histone exchange. Part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including adult dorsal vessel; embryonic/larval muscle system; esophageal visceral muscle; extended germ band embryo; and visceral muscle primordium. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Act87E in Genome Data Viewer
Location:
87E11-87E11; 3-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13425983..13428375)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9251705..9254097)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene yellow-e Neighboring gene Ionotropic receptor 87a Neighboring gene long non-coding RNA:CR45591 Neighboring gene yurt Neighboring gene long non-coding RNA:CR42756

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diagnostic amino acids in actin genes: an idea whose time has gone. White ME, et al. Mol Biol Evol, 1999 Jun. PMID 10368964
  2. Molecular genetics of actin function. Hennessey ES, et al. Biochem J, 1993 May 1. PMID 8489492, Free PMC Article
  3. The actin genes of Drosophila: a dispersed multigene family. Fyrberg EA, et al. Cell, 1980 Feb. PMID 6244106
  4. SETD3 protein is the actin-specific histidine N-methyltransferase. Kwiatkowski S, et al. Elife, 2018 Dec 11. PMID 30526847, Free PMC Article
  5. Contribution of sequence variation in Drosophila actins to their incorporation into actin-based structures in vivo. Röper K, et al. J Cell Sci, 2005 Sep 1. PMID 16105877

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
actin 87E
Names
Act87E-PA
Act87E-PB
Act87E-PC
CG18290-PA
CG18290-PB
CG18290-PC
F-actin
actin
actin87E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13425983..13428375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300385.1 → NP_001287314.1  actin 87E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287314.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2T6, P10981, Q5U0U0, Q8MZ23, Q9VFU9
    UniProtKB/TrEMBL
    A0A0B4LH50, C6TP14
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional

  2. NM_057743.5 → NP_477091.1  actin 87E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477091.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2T6, P10981, Q5U0U0, Q8MZ23, Q9VFU9
    UniProtKB/TrEMBL
    A0A0B4LH50, C6TP14
    Related
    FBpp0082253
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional

  3. NM_169525.2 → NP_731812.1  actin 87E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2T6, P10981, Q5U0U0, Q8MZ23, Q9VFU9
    UniProtKB/TrEMBL
    A0A0B4LH50, C6TP14
    Related
    FBpp0082254
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LH50 A0A0B4LH50
P10981.1 P10981

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