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NPPC natriuretic peptide C [ Homo sapiens (human) ]

Gene ID: 4880, updated on 4-Jan-2025

Summary

Official Symbol
NPPCprovided by HGNC
Official Full Name
natriuretic peptide Cprovided by HGNC
Primary source
HGNC:HGNC:7941
See related
Ensembl:ENSG00000163273 MIM:600296; AllianceGenome:HGNC:7941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNP; CNP2
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Annotation information
Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Expression
Biased expression in prostate (RPKM 1.1), esophagus (RPKM 0.4) and 9 other tissues See more
Orthologs
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Genomic context

See NPPC in Genome Data Viewer
Location:
2q37.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (231921809..231926396, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232408446..232413033, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232786519..232791106, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12450 Neighboring gene guanidinoacetate N-methyltransferase pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232769840-232770458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:232770459-232771076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232791796-232792450 Neighboring gene microRNA 1471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12454 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:232854631-232855252 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene MPRA-validated peak4085 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr2:232986245-232986439 Neighboring gene Sharpr-MPRA regulatory region 7061 Neighboring gene microRNA 562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233096173-233096674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12457 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:233141549-233142064 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:233156819-233157542 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:233157543-233158264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233194285-233195258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233197669-233198468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:233198469-233199268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233201669-233202468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233207551-233208060 Neighboring gene NRBF2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity  
enables hormone receptor binding  
enables hormone receptor binding PubMed 
enables signaling receptor binding PubMed 
Items 1 - 25 of 37
Process Evidence Code Pubs
involved_in angiogenesis  
involved_in blood vessel diameter maintenance  
involved_in blood vessel remodeling  
involved_in c-di-GMP signaling  
involved_in cGMP biosynthetic process  
acts_upstream_of cGMP biosynthetic process PubMed 
involved_in cGMP-mediated signaling  
involved_in cellular response to glycoprotein  
involved_in chromosome organization  
involved_in cumulus cell differentiation  
involved_in gastric emptying  
involved_in growth plate cartilage chondrocyte differentiation  
involved_in growth plate cartilage chondrocyte proliferation  
involved_in intracellular calcium ion homeostasis  
involved_in meiotic cell cycle process involved in oocyte maturation  
involved_in multicellular organismal locomotion  
involved_in negative regulation of DNA biosynthetic process  
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of collagen biosynthetic process  
acts_upstream_of_or_within negative regulation of meiotic cell cycle PubMed 
involved_in negative regulation of neuron apoptotic process  
acts_upstream_of_or_within negative regulation of oocyte maturation PubMed 
involved_in ossification  
involved_in positive regulation of cGMP-mediated signaling  
involved_in positive regulation of osteoblast differentiation  
involved_in post-embryonic development  
involved_in protein folding PubMed 
involved_in receptor guanylyl cyclase signaling pathway  
involved_in receptor guanylyl cyclase signaling pathway PubMed 
involved_in regulation of multicellular organism growth  
involved_in regulation of smooth muscle cell proliferation  
involved_in response to axon injury  
involved_in response to ethanol  
involved_in response to hypoxia  
involved_in response to ischemia  
involved_in response to oxygen-glucose deprivation  
involved_in response to xenobiotic stimulus  
Items 1 - 25 of 37
Component Evidence Code Pubs
located_in extracellular region  
located_in extracellular space  
part_of protein-containing complex PubMed 
located_in secretory granule  

General protein information

Preferred Names
C-type natriuretic peptide
Names
natriuretic peptide precursor type C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024409.4NP_077720.1  C-type natriuretic peptide preproprotein

    See identical proteins and their annotated locations for NP_077720.1

    Status: REVIEWED

    Source sequence(s)
    AC013435, D20847, DR003533, JF420840
    Consensus CDS
    CCDS2489.1
    UniProtKB/Swiss-Prot
    P23582, Q4ZG41
    Related
    ENSP00000387159.1, ENST00000409852.2
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    231921809..231926396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511245.4XP_011509547.1  C-type natriuretic peptide isoform X1

    See identical proteins and their annotated locations for XP_011509547.1

    UniProtKB/Swiss-Prot
    P23582, Q4ZG41
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    232408446..232413033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342295.1XP_054198270.1  C-type natriuretic peptide isoform X1

    UniProtKB/Swiss-Prot
    P23582, Q4ZG41
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