PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PIK3CAprovided by VGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:44555
See related: Ensembl:ENSCAFG00845015587
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 34

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	34	NC_051838.1 (12496918..12576076)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	34	NC_006616.4 (16743641..16822678)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	34	NC_049255.1 (12771120..12850124)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	34	NC_049294.1 (12551928..12630858)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	34	NC_049775.1 (12531843..12610836)

Chromosome 34 - NC_051838.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PIK3CA mutations matter for cancer in dogs.
Title: PIK3CA mutations matter for cancer in dogs.
We assessed the genomic landscape of canine hemangiosarcoma via whole-exome sequencing (47 golden retriever hemangiosarcomas) and RNA sequencing (74 hemangiosarcomas from multiple breeds). Somatic coding mutations occurred most frequently in the tumor suppressor TP53 (59.6% of cases) as well as two genes in the PI3K pathway: the oncogene PIK3CA (29.8%) and its regulatory subunit PIK3R1 (8.5%).
Title: Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.
IGF-1 and PDGF-bb are potent inhibitors of IL-1beta-mediated activation of NF-kappaB and apoptosis in chondrocytes, may be mediated in part through suppression of Src/PI-3K/AKT pathway.
Title: IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

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Pathways from PubChem

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General gene information

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Markers

PIK3CA_4031 (e-PCR)
- UniSTS:462410

GDB:596369 (e-PCR)
- UniSTS:158097

GDB:596374 (e-PCR)
- UniSTS:158098

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IB	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Names: phosphoinositide-3-kinase, catalytic, alpha polypeptide

XP_022270060.1

EC 2.7.1.153

XP_038301515.1

EC 2.7.1.153

XP_038301516.1

EC 2.7.1.153

XP_038301517.1

EC 2.7.1.153

XP_038318672.1

EC 2.7.1.153

XP_038375694.1

EC 2.7.1.153

XP_038375695.1

EC 2.7.1.153

XP_038375696.1

EC 2.7.1.153

XP_038439333.1

EC 2.7.1.153

XP_038439334.1

EC 2.7.1.153

XP_038439335.1

EC 2.7.1.153

XP_038503747.1

EC 2.7.1.153

XP_038503748.1

EC 2.7.1.153

XP_038503749.1

EC 2.7.1.153

XP_545208.2

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051838.1 Reference ROS_Cfam_1.0

Range

12496918..12576076

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038445587.1 → XP_038301515.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Related

ENSCAFP00845021905.1, ENSCAFT00845027831.1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038445588.1 → XP_038301516.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038445589.1 → XP_038301517.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049294.1 Alternate UMICH_Zoey_3.1

Range

12551928..12630858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038519766.1 → XP_038375694.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038519767.1 → XP_038375695.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038519768.1 → XP_038375696.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049775.1 Alternate UNSW_CanFamBas_1.0

Range

12531843..12610836

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038647819.1 → XP_038503747.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038647820.1 → XP_038503748.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038647821.1 → XP_038503749.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049255.1 Alternate UU_Cfam_GSD_1.0

Range

12771120..12850124

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038583405.1 → XP_038439333.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038583406.1 → XP_038439334.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038583407.1 → XP_038439335.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

16743641..16822678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_545208.7 → XP_545208.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

See identical proteins and their annotated locations for XP_545208.2

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_038462744.1 → XP_038318672.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain
XM_022414352.2 → XP_022270060.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProtKB/TrEMBL

A0A5F4C2B1, A0A8C0LET4, A0A8C0T4B1, A0A8C0T7K1

Conserved Domains (5) summary

cd08398
Location:325 → 484

C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:173 → 292

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:525 → 696

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05175
Location:695 → 1064

PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain