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PDE8A phosphodiesterase 8A [ Canis lupus familiaris (dog) ]

Gene ID: 488752, updated on 5-Mar-2024

Summary

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Official Symbol
PDE8Aprovided by VGNC
Official Full Name
phosphodiesterase 8Aprovided by VGNC
Primary source
VGNC:VGNC:44365
See related
Ensembl:ENSCAFG00845003266
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (54631013..54787194)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (56852891..57008693)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (54702916..54859444)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (54151873..54307649)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (54360516..54516720)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 member 1 Neighboring gene 60S ribosomal protein L17-like Neighboring gene small nucleolar RNA U3 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene uncharacterized LOC119871212

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
XP_022272671.1
XP_038327911.1
XP_038327912.1
XP_038327913.1
XP_038327914.1
XP_038331901.1
XP_038331912.1
XP_038331919.1
XP_038388850.1
XP_038388851.1
XP_038388852.1
XP_038388853.1
XP_038453178.1
XP_038453179.1
XP_038453180.1
XP_038453181.1
XP_038517352.1
XP_038517353.1
XP_038517354.1
XP_038517355.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    54631013..54787194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038661424.1 → XP_038517352.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q553, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  2. XM_038661425.1 → XP_038517353.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q2E3, A0A8C0Q553, A0A8I3MLG5, A0A8I3MSA3
    Related
    ENSCAFP00845004613.1, ENSCAFT00845005811.1
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 812
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  3. XM_038661426.1 → XP_038517354.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q553, A0A8I3MSA3
    Related
    ENSCAFP00845004655.1, ENSCAFT00845005858.1
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:533 → 791
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  4. XM_038661427.1 → XP_038517355.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    UniProtKB/TrEMBL
    A0A8I3MQ45, A0A8P0NEX6
    Related
    ENSCAFP00845004746.1, ENSCAFT00845005964.1
    Conserved Domains (3) summary
    COG0745
    Location:10 → 97
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:483 → 741
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154 → 252
    PAS_9; PAS domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    54151873..54307649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471983.1 → XP_038327911.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  2. XM_038471984.1 → XP_038327912.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 812
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  3. XM_038471985.1 → XP_038327913.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:533 → 791
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  4. XM_038471986.1 → XP_038327914.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    Conserved Domains (3) summary
    COG0745
    Location:10 → 97
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:483 → 741
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154 → 252
    PAS_9; PAS domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    54360516..54516720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038597250.1 → XP_038453178.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  2. XM_038597251.1 → XP_038453179.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 812
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  3. XM_038597252.1 → XP_038453180.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:533 → 791
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  4. XM_038597253.1 → XP_038453181.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    Conserved Domains (3) summary
    COG0745
    Location:10 → 97
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:483 → 741
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154 → 252
    PAS_9; PAS domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    54702916..54859444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532922.1 → XP_038388850.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q553, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  2. XM_038532923.1 → XP_038388851.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q2E3, A0A8C0Q553, A0A8I3MLG5, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 812
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  3. XM_038532924.1 → XP_038388852.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q553, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:533 → 791
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  4. XM_038532925.1 → XP_038388853.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    UniProtKB/TrEMBL
    A0A8I3MQ45, A0A8P0NEX6
    Conserved Domains (3) summary
    COG0745
    Location:10 → 97
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:483 → 741
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154 → 252
    PAS_9; PAS domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    56852891..57008693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475973.1 → XP_038331901.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    UniProtKB/TrEMBL
    A0A8C0Q553, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 817
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  2. XM_038475984.1 → XP_038331912.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q2E3, A0A8C0Q553, A0A8I3MLG5, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:559 → 812
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  3. XM_038475991.1 → XP_038331919.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q553, A0A8I3MSA3
    Conserved Domains (4) summary
    COG0745
    Location:86 → 173
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:533 → 791
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 59
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:230 → 328
    PAS_9; PAS domain

  4. XM_022416963.2 → XP_022272671.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

    UniProtKB/TrEMBL
    A0A8I3MQ45, A0A8P0NEX6
    Conserved Domains (3) summary
    COG0745
    Location:10 → 97
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:483 → 741
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154 → 252
    PAS_9; PAS domain
Nucleotide Protein
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