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HMBS hydroxymethylbilane synthase [ Canis lupus familiaris (dog) ]

Gene ID: 489373, updated on 5-Mar-2024

Summary

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Official Symbol
HMBSprovided by VGNC
Official Full Name
hydroxymethylbilane synthaseprovided by VGNC
Primary source
VGNC:VGNC:41704
See related
Ensembl:ENSCAFG00845000569
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (14710999..14718527, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (14820660..14828175, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (14793431..14800910, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (14849036..14856511, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (14753058..14760536, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119871800 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC106558794 Neighboring gene uncharacterized LOC102154262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylbilane synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-pyrromethane cofactor linkage IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
porphobilinogen deaminase
XP_005619738.1
XP_005619739.1
XP_013968850.1
XP_038330730.1
XP_038330731.1
XP_038330732.1
XP_038330733.1
XP_038330734.1
XP_038364412.1
XP_038391877.1
XP_038391878.1
XP_038391879.1
XP_038391880.1
XP_038391881.1
XP_038456071.1
XP_038456072.1
XP_038456073.1
XP_038456074.1
XP_038456075.1
XP_038520609.1
XP_038520610.1
XP_038520611.1
XP_038520612.1
XP_038520613.1
XP_546491.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    14710999..14718527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664681.1 → XP_038520609.1  porphobilinogen deaminase isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJF2, A0A8C0M407, A0A8C0TFA4, A0A8I3RP95
    Related
    ENSCAFP00845000745.1, ENSCAFT00845000983.1
    Conserved Domains (1) summary
    cd13645
    Location:20 → 299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  2. XM_038664682.1 → XP_038520610.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  3. XM_038664684.1 → XP_038520612.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  4. XM_038664685.1 → XP_038520613.1  porphobilinogen deaminase isoform X3

    UniProtKB/TrEMBL
    A0A8C0Z382
    Conserved Domains (1) summary
    cd13645
    Location:1 → 244
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  5. XM_038664683.1 → XP_038520611.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    14849036..14856511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038474802.1 → XP_038330730.1  porphobilinogen deaminase isoform X1

    Conserved Domains (1) summary
    cd13645
    Location:20 → 299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  2. XM_038474803.1 → XP_038330731.1  porphobilinogen deaminase isoform X2

    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  3. XM_038474805.1 → XP_038330733.1  porphobilinogen deaminase isoform X2

    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  4. XM_038474806.1 → XP_038330734.1  porphobilinogen deaminase isoform X3

    Conserved Domains (1) summary
    cd13645
    Location:1 → 244
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  5. XM_038474804.1 → XP_038330732.1  porphobilinogen deaminase isoform X2

    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    14753058..14760536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038600143.1 → XP_038456071.1  porphobilinogen deaminase isoform X1

    Conserved Domains (1) summary
    cd13645
    Location:20 → 299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  2. XM_038600144.1 → XP_038456072.1  porphobilinogen deaminase isoform X2

    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  3. XM_038600146.1 → XP_038456074.1  porphobilinogen deaminase isoform X2

    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  4. XM_038600147.1 → XP_038456075.1  porphobilinogen deaminase isoform X3

    Conserved Domains (1) summary
    cd13645
    Location:1 → 244
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  5. XM_038600145.1 → XP_038456073.1  porphobilinogen deaminase isoform X2

    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    14793431..14800910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535949.1 → XP_038391877.1  porphobilinogen deaminase isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJF2, A0A8C0M407, A0A8C0TFA4, A0A8I3RP95
    Conserved Domains (1) summary
    cd13645
    Location:20 → 299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  2. XM_038535950.1 → XP_038391878.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  3. XM_038535952.1 → XP_038391880.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  4. XM_038535953.1 → XP_038391881.1  porphobilinogen deaminase isoform X3

    UniProtKB/TrEMBL
    A0A8C0Z382
    Conserved Domains (1) summary
    cd13645
    Location:1 → 244
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  5. XM_038535951.1 → XP_038391879.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    14820660..14828175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546491.7 → XP_546491.2  porphobilinogen deaminase isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJF2, A0A8C0M407, A0A8C0TFA4, A0A8I3RP95
    Conserved Domains (1) summary
    cd13645
    Location:20 → 299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  2. XM_005619682.4 → XP_005619739.1  porphobilinogen deaminase isoform X2

    See identical proteins and their annotated locations for XP_005619739.1

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  3. XM_038508484.1 → XP_038364412.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  4. XM_014113375.3 → XP_013968850.1  porphobilinogen deaminase isoform X3

    UniProtKB/TrEMBL
    A0A8C0Z382
    Conserved Domains (1) summary
    cd13645
    Location:1 → 244
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

  5. XM_005619681.4 → XP_005619738.1  porphobilinogen deaminase isoform X2

    See identical proteins and their annotated locations for XP_005619738.1

    UniProtKB/TrEMBL
    A0A8C0M9C0, A0A8C0TCQ7
    Conserved Domains (1) summary
    cd13645
    Location:3 → 282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
Nucleotide Protein
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