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Atpalpha Na pump alpha subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48971, updated on 4-Jan-2025

Summary

Official Symbol
Atpalphaprovided by FlyBase
Official Full Name
Na pump alpha subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0002921
Locus tag
Dmel_CG5670
See related
AllianceGenome:FB:FBgn0002921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
(Na[+]/k[+])-ATPase; alpha-ATPase; Atp; Atp a; ATP-alpha; Atpa; ATPa; atpalpha; ATPalpha; ATPalpha1; ATPBagr; CG5670; Da-47; Dmel\CG5670; dnATPase; JY; K ATPase; K-ATPase; K[+] -ATPase; K[+]-ATPase; K[+]-ATPase alpha subunit; K[+]-ATPase alpha-subunit; l(3)01164; l(3)01453; l(3)04492; l(3)j3B2; l(3)j3B7; l(3)j6A4; l(3)rM454; l(3)ry136; Na; Na+-K+-ATPase; Na+/K+ ATPase alpha subunit; Na+/K+-ATPase; Na-p; Na/K ATPase; Na/K-ATPase; Na/K-ATPase alpha-subunit; NaK; NaK ATPase; NaK-ATPase; Na[+]; Na[+]-K[+]-ATPase alpha[[5]]-subunit; Na[+]/K[+] ATPase; Na[+]/K[+]-ATPase; Na[+]/K[+]ATPase; Na[+]K[+] ATPase; Na[+]K[+]-ATPase; Na[+]K[+]ATPase; Na[+]K[+]ATPase-alpha; NKA; sodium/potassium transporting ATPase alpha
Summary
Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including cell junction assembly; determination of adult lifespan; and respiratory system development. Located in basolateral plasma membrane; nucleus; and septate junction. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including brain; epithelial cell; organism subdivision; salivary gland; and synaptic neuropil domain. Used to study Charcot-Marie-Tooth disease type 2DD; epilepsy; familial hemiplegic migraine; and nervous system disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; bipolar disorder; brain disease (multiple); and hypertension. Orthologous to several human genes including ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Atpalpha in Genome Data Viewer
Location:
93A4-93A4; 3-69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20948714..20976239)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16774436..16801961)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene antisense RNA:CR44106 Neighboring gene uncharacterized protein Neighboring gene hadley Neighboring gene Na/Ca-exchange protein Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in adult locomotory behavior PubMed 
involved_in chemical synaptic transmission PubMed 
involved_in determination of adult lifespan PubMed 
involved_in intracellular potassium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in jump response PubMed 
involved_in locomotory behavior PubMed 
involved_in monoatomic cation transport PubMed 
involved_in neuromuscular process PubMed 
involved_in potassium ion import across plasma membrane  
involved_in potassium ion transport  
involved_in proton transmembrane transport  
involved_in regulation of tube diameter, open tracheal system PubMed 
involved_in regulation of tube length, open tracheal system PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to temperature stimulus PubMed 
involved_in sensory perception of sound PubMed 
involved_in septate junction assembly PubMed 
involved_in sodium ion export across plasma membrane  
involved_in synaptic assembly at neuromuscular junction PubMed 
involved_in tissue homeostasis PubMed 
involved_in trachea morphogenesis PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane PubMed 
located_in cytoplasm PubMed 
located_in membrane  
located_in nucleus PubMed 
located_in plasma membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in septate junction PubMed 
part_of sodium:potassium-exchanging ATPase complex PubMed 

General protein information

Preferred Names
Na pump alpha subunit
Names
(Na[+] + K[+])-ATPase alpha-subunit
(Na[+],K[+])ATPase alpha subunit
ATPalpha
ATPase alpha
ATPase alpha subunit
Atpalpha-PA
Atpalpha-PB
Atpalpha-PC
Atpalpha-PD
Atpalpha-PE
Atpalpha-PF
Atpalpha-PG
Atpalpha-PH
Atpalpha-PI
Atpalpha-PJ
Atpalpha-PK
CG5670-PA
CG5670-PB
CG5670-PC
CG5670-PD
CG5670-PE
CG5670-PF
CG5670-PG
CG5670-PH
CG5670-PI
CG5670-PJ
CG5670-PK
Na+,K+ ATPase alpha-subunit
Na+K+ ATPase alpha subunit
Na, K ATPase a subunit
Na,K ATPase
Na,K ATPase alpha subunit
Na,K-ATPase
Na,K-ATPase alpha
Na,K-ATPase alpha subunit
Na,K-ATPase alpha-subunit
NaK-ATPase
Na[ +], K[ +] -ATPase
Na[+] pump alpha subunit
Na[+], K[+] ATPase alpha
Na[+],K[+] ATPase alpha subunit
Na[+],K[+]-ATPase alpha subunit
Na[+]-K[+] ATPase
Na[+]/K[+] ATPase (alpha subunit)
Na[+]/K[+] ATPase alpha subunit
Na[+]/K[+]-ATPase
Na[+]K[+] ATPase alpha subunit
Na[+]K[+]ATPase
alpha-subunit of ATPase
sodium pump alpha subunit
sodium pump alpha-subunit
NP_001163667.1
NP_001262790.1
NP_001262791.1
NP_732572.1
NP_732573.1
NP_732574.1
NP_732575.1
NP_996247.1
NP_996248.1
NP_996249.1
NP_996250.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20948714..20976239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275861.1 → NP_001262790.1  Na pump alpha subunit, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGG8, C8VUY7, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  2. NM_001170196.3 → NP_001163667.1  Na pump alpha subunit, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUY7, E1JIR4, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  3. NM_169938.3 → NP_732574.1  Na pump alpha subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGG8, C8VUY7, I7J4E4
    Related
    FBpp0088501
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  4. NM_206527.3 → NP_996249.1  Na pump alpha subunit, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996249.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUY7, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  5. NM_206526.3 → NP_996248.1  Na pump alpha subunit, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996248.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUY7, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  6. NM_001275862.2 → NP_001262791.1  Na pump alpha subunit, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGG8, C8VUY7, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  7. NM_169936.3 → NP_732572.1  Na pump alpha subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732572.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V366, A4V367, O61494, P13607, Q0KI37, Q7KS94, Q7KS95, Q86MY6, Q86MY7, Q86MY8, Q86MY9, Q86MZ0, Q8IN40, Q8T0L8, Q9VDG6, Q9VDG7, Q9VDG8
    UniProtKB/TrEMBL
    C8VUY7, H9ZJM5, I7J4E4
    Related
    FBpp0088502
    Conserved Domains (6) summary
    smart00831
    Location:58 → 132
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:695 → 770
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:45 → 1041
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:152 → 383
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:817 → 1025
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:445 → 539
    Cation_ATPase; Cation transport ATPase (P-type)
  8. NM_206528.3 → NP_996250.1  Na pump alpha subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996250.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGG8, C8VUY7, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  9. NM_169939.2 → NP_732575.1  Na pump alpha subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RIT8, E6PBW0
    Related
    FBpp0088504
    Conserved Domains (5) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01494
    Location:114 → 787
    ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  10. NM_206525.3 → NP_996247.1  Na pump alpha subunit, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996247.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUY7, I7J4E4
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
  11. NM_169937.3 → NP_732573.1  Na pump alpha subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGG8, C8VUY7, I7J4E4
    Related
    FBpp0088503
    Conserved Domains (6) summary
    smart00831
    Location:19 → 93
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:656 → 731
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:6 → 1002
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:113 → 344
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:778 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:406 → 500
    Cation_ATPase; Cation transport ATPase (P-type)
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