Replication interactions
Interaction |
Pubs |
Knockdown of nucleoporin 98kDa (NUP98) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
PubMed
|
Knockdown of nucleoporin 98kDa (NUP98) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Rev
|
rev
|
nup98 is involved in Rev-mediated nuclear export of HIV-1 mRNA through an interaction with eukaryotic initiation factor 5A (eIF-5A) which binds to Rev |
PubMed
|
|
rev
|
the FG repeat region of nup98 interacts directly with the nuclear export sequence of HIV-1 Rev, suggesting a physiological role for nup98 in modulating Rev-dependent RNA export during HIV infection |
PubMed
|
|
rev
|
Rev can recruit nup98 to the nucleolus |
PubMed
|
|
rev
|
the FG-containing repeat domain of Nup98 can inhibit Rev-mediated expression of viral proteins |
PubMed
|
Tat
|
tat
|
Interaction of HIV-1 Tat with Nup98 in T-cells is identified by a proteomic strategy based on affinity chromatography |
PubMed
|
capsid
|
gag
|
Nucleoporins NUP153 and NUP98 bind in vitro assembled HIV-1 CA-NC complexes, suggesting that both nucleoporins bind the HIV-1 core during the early stages of infection |
PubMed
|
integrase
|
gag-pol
|
Nucleoporin 98kD protein (NUP98) is involved in nuclear import for HIV-1 integration by IN |
PubMed
|
nucleocapsid
|
gag
|
Nucleoporins NUP153 and NUP98 bind in vitro assembled HIV-1 CA-NC complexes, suggesting that both nucleoporins bind the HIV-1 core during the early stages of infection |
PubMed
|
Go to the HIV-1, Human Interaction Database