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Crppa CDP-L-ribitol pyrophosphorylase A [ Rattus norvegicus (Norway rat) ]

Gene ID: 493574, updated on 2-May-2024

Summary

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Official Symbol
Crppaprovided by RGD
Official Full Name
CDP-L-ribitol pyrophosphorylase Aprovided by RGD
Primary source
RGD:1359368
See related
Ensembl:ENSRNOG00000006199 AllianceGenome:RGD:1359368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nip; Ispd
Summary
Predicted to enable D-ribitol-5-phosphate cytidylyltransferase activity and protein homodimerization activity. Predicted to be involved in protein O-linked mannosylation. Predicted to act upstream of or within axon guidance and protein glycosylation. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2U and congenital muscular dystrophy-dystroglycanopathy A7. Orthologous to human CRPPA (CDP-L-ribitol pyrophosphorylase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 42.2), Kidney (RPKM 35.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crppa in Genome Data Viewer
Location:
6q16-q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (58847550..59124309)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (53120264..53397030)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (55880136..56159466)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 4 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 2 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation. Riemersma M, et al. Chem Biol, 2015 Dec 17. PMID 26687144
  2. ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome. Willer T, et al. Nat Genet, 2012 May. PMID 22522420, Free PMC Article
  3. Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan. Roscioli T, et al. Nat Genet, 2012 May. PMID 22522421, Free PMC Article
  4. Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Wright KM, et al. Neuron, 2012 Dec 6. PMID 23217742, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-ribitol-5-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribitol-5-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-ribitol-5-phosphate cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables D-ribitol-5-phosphate cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
D-ribitol-5-phosphate cytidylyltransferase
Names
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein
isoprenoid synthase domain containing
isoprenoid synthase domain-containing protein
notch1-induced protein
NP_001008387.1
XP_038968597.1
XP_038968598.1
XP_063118333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008386.1 → NP_001008387.1  D-ribitol-5-phosphate cytidylyltransferase

    See identical proteins and their annotated locations for NP_001008387.1

    Status: PROVISIONAL

    Source sequence(s)
    AY769992
    UniProtKB/Swiss-Prot
    Q5S6T3, Q5S6T4
    UniProtKB/TrEMBL
    A0A8I6AE23
    Related
    ENSRNOP00000008312.4, ENSRNOT00000008312.5
    Conserved Domains (1) summary
    cd02516
    Location:45 → 271
    CDP-ME_synthetase; CDP-ME synthetase is involved in mevalonate-independent isoprenoid production

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    58847550..59124309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112670.1 → XP_038968598.1  D-ribitol-5-phosphate cytidylyltransferase isoform X2

    Conserved Domains (2) summary
    pfam18706
    Location:182 → 348
    ISPD_C; D-ribitol-5-phosphate cytidylyltransferase C-terminal domain
    cl11394
    Location:1 → 172
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_039112669.2 → XP_038968597.1  D-ribitol-5-phosphate cytidylyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K627, A0A8I6AE23
    Related
    ENSRNOP00000073650.2
    Conserved Domains (2) summary
    cd02516
    Location:45 → 271
    CDP-ME_synthetase; CDP-ME synthetase is involved in mevalonate-independent isoprenoid production
    pfam18706
    Location:281 → 413
    ISPD_C; D-ribitol-5-phosphate cytidylyltransferase C-terminal domain

  3. XM_063262263.1 → XP_063118333.1  D-ribitol-5-phosphate cytidylyltransferase isoform X3

RNA

  1. XR_005505559.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5S6T3.1 GenPept UniProtKB/Swiss-Prot:Q5S6T3

Gene LinkOut

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