ADRB1 adrenoceptor beta 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ADRB1provided by VGNC
Official Full Name: adrenoceptor beta 1provided by VGNC
Primary source: VGNC:VGNC:37676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	28	NC_051832.1 (25441579..25443005)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	28	NC_006610.4 (25059492..25060922)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	28	NC_049249.1 (25206065..25207486)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	28	NC_049288.1 (24997230..24998684)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	28	NC_049769.1 (25011917..25013353)

Chromosome 28 - NC_051832.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cardiac pacemaker improves rest and beta-adrenergic-stimulated myocyte function and calcium handling, upregulating beta(1) receptors and adenylate cyclase activity and suppressing G(i)-coupled signaling associated with novel RGS upregulation
Title: Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy.
Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta1-receptor blockade.
Title: Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade.
Report dissociation between cardiomyocyte function and remodeling with beta1-adrenergic receptor blockade in isolated canine mitral regurgitation.
Title: Dissociation between cardiomyocyte function and remodeling with beta-adrenergic receptor blockade in isolated canine mitral regurgitation.

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General gene information

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Markers

Adrb1 (e-PCR), detects polymorphism
- UniSTS:256461

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables beta1-adrenergic receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of heart rate by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-1 adrenergic receptor

Names: beta-1 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008713.2 → NP_001008713.2 beta-1 adrenergic receptor

Status: VALIDATED

Source sequence(s)

AAEX03015538

UniProtKB/TrEMBL

A0A8C0TGK3

Conserved Domains (2) summary

pfam00001
Location:75 → 376

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:67 → 266

7tm_4; Olfactory receptor