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Pms1 PMS1 homolog 1, mismatch repair system component [ Rattus norvegicus (Norway rat) ]

Gene ID: 494322, updated on 5-Mar-2024

Summary

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Symbol
Pms1provided by RGD
Full Name
PMS1 homolog 1, mismatch repair system componentprovided by RGD
Primary source
RGD:1359511
See related
Ensembl:ENSRNOG00000004076 AllianceGenome:RGD:1359511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity and enzyme binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; dermatomyositis; pancreatic ductal carcinoma; and polymyositis. Orthologous to human PMS1 (PMS1 homolog 1, mismatch repair system component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 79.5), Thymus (RPKM 70.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pms1 in Genome Data Viewer
Location:
9q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (55721393..55832225)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48229403..48340237)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53120656..53206520)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 40 member 1 Neighboring gene ASNSD1 upstream open reading frame Neighboring gene asparagine synthetase domain containing 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene O-sialoglycoprotein endopeptidase-like 1 Neighboring gene ORMDL sphingolipid biosynthesis regulator 1 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene myostatin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. Okada T, et al. Int J Cancer, 2005 Oct 10. PMID 15856462
  2. Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide. Vinson RK, et al. Teratology, 2001 Dec. PMID 11754170
  3. DNA mismatch repair defects: role in colorectal carcinogenesis. Jacob S, et al. Biochimie, 2002 Jan. PMID 11900875
  4. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nicolaides NC, et al. Nature, 1994 Sep 1. PMID 8072530
  5. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Prolla TA, et al. Nat Genet, 1998 Mar. PMID 9500552

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC72584

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mismatch repair ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of MutLalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PMS1 protein homolog 1
Names
PMS1 postmeiotic segregation increased 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009535.1 → NP_001009535.1  PMS1 protein homolog 1

    See identical proteins and their annotated locations for NP_001009535.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061722
    UniProtKB/TrEMBL
    A0A8I6AGZ9, Q6P7D0
    Conserved Domains (4) summary
    cd01390
    Location:561 → 625
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    cd03485
    Location:205 → 338
    MutL_Trans_hPMS_1_like; MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is ...
    TIGR00585
    Location:1 → 318
    mutl; DNA mismatch repair protein MutL
    pfam02518
    Location:18 → 102
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    55721393..55832225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084041.1 → XP_038939969.1  PMS1 protein homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGZ9, D4A651
    Conserved Domains (2) summary
    cd01390
    Location:561 → 625
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    TIGR00585
    Location:1 → 318
    mutl; DNA mismatch repair protein MutL

  2. XM_039084044.2 → XP_038939972.1  PMS1 protein homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGZ9, D4A651
    Conserved Domains (2) summary
    cd01390
    Location:561 → 625
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    TIGR00585
    Location:1 → 318
    mutl; DNA mismatch repair protein MutL

  3. XM_039084043.2 → XP_038939971.1  PMS1 protein homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGZ9, D4A651
    Conserved Domains (2) summary
    cd01390
    Location:561 → 625
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    TIGR00585
    Location:1 → 318
    mutl; DNA mismatch repair protein MutL

  4. XM_039084042.2 → XP_038939970.1  PMS1 protein homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGZ9, D4A651
    Related
    ENSRNOP00000047584.4
    Conserved Domains (2) summary
    cd01390
    Location:561 → 625
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    TIGR00585
    Location:1 → 318
    mutl; DNA mismatch repair protein MutL

  5. XM_039084045.2 → XP_038939973.1  PMS1 protein homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGZ9, D4A651
    Conserved Domains (2) summary
    cd01390
    Location:561 → 625
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    TIGR00585
    Location:1 → 318
    mutl; DNA mismatch repair protein MutL

  6. XM_039084046.1 → XP_038939974.1  PMS1 protein homolog 1 isoform X2

    UniProtKB/TrEMBL
    A6INU7
    Conserved Domains (2) summary
    cd01390
    Location:354 → 418
    HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
    cd03485
    Location:1 → 131
    MutL_Trans_hPMS_1_like; MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is ...

RNA

  1. XR_010054623.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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