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Srsf2 serine and arginine rich splicing factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 494445, updated on 13-Apr-2024

Summary

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Official Symbol
Srsf2provided by RGD
Official Full Name
serine and arginine rich splicing factor 2provided by RGD
Primary source
RGD:1359422
See related
Ensembl:ENSRNOG00000000248 AllianceGenome:RGD:1359422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sfrs2
Summary
Enables protein kinase C binding activity. Involved in mitotic cell cycle and response to vitamin E. Located in interchromatin granule; nuclear speck; and perichromatin fibrils. Human ortholog(s) of this gene implicated in acute myeloid leukemia; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 877.7), Spleen (RPKM 660.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srsf2 in Genome Data Viewer
Location:
10q32.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102550962..102554200, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102052158..102055365, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105792779..105795986, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene methyltransferase 23, arginine Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Sharma S, et al. Mol Cancer Ther, 2011 Sep. PMID 21764905, Free PMC Article
  2. Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress. Bryantsev AL, et al. Exp Cell Res, 2007 Jan 1. PMID 17123510, Free PMC Article
  3. Aging and vitamin E deficiency are responsible for altered RNA pathways. Malatesta M, et al. Ann N Y Acad Sci, 2004 Jun. PMID 15247049
  4. Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Zaidi SK, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657346, Free PMC Article
  5. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states. Sahlas DJ, et al. J Cell Sci, 1993 Jun. PMID 8408269

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. phosphorylated PKCdelta activates SC35 splicing factor during H9c2 cardiomyoblastic differentiation
    Title: pPKCδ activates SC35 splicing factor during H9c2 myoblastic differentiation.
  2. these results could indicate that myocardial tissue adaptation to low oxygen tension needs the activation of SC-35 mediated by PKC.
    Title: Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue.
  3. The role played by phospho-Protein Kinase C-alpha (p-PKCalpha) in regulating the activation of SC-35 splicing factor, was studied.
    Title: Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC73009

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in interchromatin granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perichromatin fibrils IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 2
Names
SC-35
splicing component, 35 kDa
splicing factor SC35
splicing factor, arginine/serine-rich 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009720.2 → NP_001009720.1  serine/arginine-rich splicing factor 2

    See identical proteins and their annotated locations for NP_001009720.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q6PDU1
    UniProtKB/TrEMBL
    A6HL00
    Related
    ENSRNOP00000059012.1, ENSRNOT00000067739.3
    Conserved Domains (1) summary
    cd12311
    Location:16 → 88
    RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    102550962..102554200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768382.3 → XP_008766604.1  serine/arginine-rich splicing factor 2 isoform X1

    See identical proteins and their annotated locations for XP_008766604.1

    UniProtKB/Swiss-Prot
    Q6PDU1
    UniProtKB/TrEMBL
    A6HL00
    Conserved Domains (1) summary
    cd12311
    Location:16 → 88
    RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

  2. XM_006247813.5 → XP_006247875.1  serine/arginine-rich splicing factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006247875.1

    UniProtKB/Swiss-Prot
    Q6PDU1
    UniProtKB/TrEMBL
    A6HL00
    Conserved Domains (1) summary
    cd12311
    Location:16 → 88
    RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RNA

  1. XR_005489902.2 RNA Sequence

  2. XR_358012.5 RNA Sequence

  3. XR_005489901.2 RNA Sequence

  4. XR_010055224.1 RNA Sequence

  5. XR_010055223.1 RNA Sequence

  6. XR_010055222.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDU1.3 GenPept UniProtKB/Swiss-Prot:Q6PDU1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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