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Mug1 murinoglobulin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497794, updated on 2-May-2024

Summary

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Symbol
Mug1provided by RGD
Full Name
murinoglobulin 1provided by RGD
Primary source
RGD:621366
See related
Ensembl:ENSRNOG00000067685 AllianceGenome:RGD:621366
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
A1i3
Summary
Predicted to enable endopeptidase inhibitor activity and protease binding activity. Involved in inflammatory response. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human PZP (PZP alpha-2-macroglobulin like) and A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 14140.2) See more
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Genomic context

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See Mug1 in Genome Data Viewer
Location:
4q42
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156748351..156802132)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (155076270..155130051)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154676382..154729288)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene murinoglobulin 1 like 1 Neighboring gene thymosin beta-10 pseudogene Neighboring gene salvador family WW domain containing protein 1, pseudogene 1 Neighboring gene uncharacterized LOC108350756 Neighboring gene murinoglobulin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tumor-associated expression of a serum protein, termed aX protein (alpha 1-inhibitor III), and its mRNA in rat liver. Sugiyama K, et al. Jpn J Cancer Res, 1989 Aug. PMID 2511184, Free PMC Article
  2. Differential regulation of the two mRNA species of the rodent negative acute phase protein alpha 1-inhibitor 3. Regler R, et al. FEBS Lett, 1991 May 6. PMID 1709877
  3. Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis. Ganaie IA, et al. Biochimie, 2020 Jul. PMID 32325114
  4. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, et al. J Biol Chem, 1988 Mar 15. PMID 2831216
  5. Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites. Esadeg S, et al. Placenta, 2003 Nov. PMID 14580373

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis.
    Title: Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
murinoglobulin-1
Names
Murinoglobulin 1 homolog
alpha x protein
alpha-1-inhibitor III
alpha-X protein
murinoglobulin-1-like
plasma proteinase inhibitor alpha-1-inhibitor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023103.1 → NP_075591.1  murinoglobulin-1 precursor

    See identical proteins and their annotated locations for NP_075591.1

    Status: PROVISIONAL

    Source sequence(s)
    X52984
    UniProtKB/Swiss-Prot
    Q03310, Q03626, Q63018, Q63020, Q63023, Q78DZ4, Q9JMK7
    UniProtKB/TrEMBL
    D4A6E3
    Related
    ENSRNOP00000019969.5, ENSRNOT00000019969.7
    Conserved Domains (6) summary
    cd02897
    Location:971 → 1277
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:751 → 841
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam07677
    Location:1389 → 1476
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1024 → 1279
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:459 → 606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    156748351..156802132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237282.5 → XP_006237344.1  murinoglobulin-1 isoform X1

    UniProtKB/TrEMBL
    D4A6E3
    Related
    ENSRNOP00000069175.2
    Conserved Domains (6) summary
    cd02897
    Location:971 → 1277
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:751 → 841
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam07677
    Location:1389 → 1476
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1024 → 1279
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:459 → 606
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03626.1 GenPept UniProtKB/Swiss-Prot:Q03626

Gene LinkOut

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