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Tmem100 transmembrane protein 100 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497979, updated on 3-Apr-2024

Summary

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Official Symbol
Tmem100provided by RGD
Official Full Name
transmembrane protein 100provided by RGD
Primary source
RGD:1560541
See related
Ensembl:ENSRNOG00000002434 AllianceGenome:RGD:1560541
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in BMP signaling pathway; positive regulation of cell differentiation; and regulation of sensory perception of pain. Predicted to act upstream of or within several processes, including circulatory system development; protein kinase B signaling; and regulation of calcium-mediated signaling. Predicted to be located in endoplasmic reticulum; perikaryon; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 1156.0) and Muscle (RPKM 127.3) See more
Orthologs
human mouse all
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Genomic context

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See Tmem100 in Genome Data Viewer
Location:
10q26
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75351891..75357748)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74854779..74861147)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (77537340..77543710)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC134480856 Neighboring gene uncharacterized LOC120095174 Neighboring gene uncharacterized LOC103693415 Neighboring gene phosphatidylcholine transfer protein Neighboring gene small integral membrane protein 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves. Eisenman ST, et al. Neuroscience, 2013 Jun 14. PMID 23485812, Free PMC Article
  2. Generation of mice with a conditional and reporter allele for Tmem100. Moon EH, et al. Genesis, 2010 Nov. PMID 20848592
  3. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Weng HJ, et al. Neuron, 2015 Feb 18. PMID 25640077, Free PMC Article
  4. Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos. Mizuta K, et al. Dev Dyn, 2015 Jan. PMID 25318679
  5. Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Somekawa S, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22783020, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108778

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within arterial endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to BMP stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocardial cushion development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within vasculogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane protein 100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017479.1 → NP_001017479.1  transmembrane protein 100

    See identical proteins and their annotated locations for NP_001017479.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092577
    UniProtKB/Swiss-Prot
    Q569C0
    UniProtKB/TrEMBL
    A6HI10
    Related
    ENSRNOP00000003297.4, ENSRNOT00000003297.8
    Conserved Domains (1) summary
    pfam16311
    Location:1 → 133
    TMEM100; Transmembrane protein 100

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    75351891..75357748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269656.1 → XP_063125726.1  transmembrane protein 100 isoform X1

    UniProtKB/Swiss-Prot
    Q569C0
    UniProtKB/TrEMBL
    A6HI10

  2. XM_063269657.1 → XP_063125727.1  transmembrane protein 100 isoform X1

    UniProtKB/Swiss-Prot
    Q569C0
    UniProtKB/TrEMBL
    A6HI10

  3. XM_039086625.2 → XP_038942553.1  transmembrane protein 100 isoform X1

    UniProtKB/Swiss-Prot
    Q569C0
    UniProtKB/TrEMBL
    A6HI10
    Related
    ENSRNOP00000097274.1
    Conserved Domains (1) summary
    pfam16311
    Location:1 → 133
    TMEM100; Transmembrane protein 100
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q569C0.1 GenPept UniProtKB/Swiss-Prot:Q569C0

Gene LinkOut

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