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Uchl3 ubiquitin C-terminal hydrolase L3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498560, updated on 3-Apr-2024

Summary

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Official Symbol
Uchl3provided by RGD
Official Full Name
ubiquitin C-terminal hydrolase L3provided by RGD
Primary source
RGD:1561196
See related
Ensembl:ENSRNOG00000009530 AllianceGenome:RGD:1561196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UCH-L3; RGD1561196
Summary
Predicted to enable thiol-dependent deubiquitinase and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of fat cell differentiation; and protein deubiquitination. Predicted to act upstream of or within adult walking behavior; eating behavior; and retina development in camera-type eye. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 143.0), Thymus (RPKM 92.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uchl3 in Genome Data Viewer
Location:
15q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (84888847..84942095)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (78485304..78527355)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (86153624..86198127)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 4 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X, pseudogene 1 Neighboring gene COMM domain containing 6 Neighboring gene HCLS1 associated protein X-1, pseudogene 3 Neighboring gene uncharacterized LOC134482002 Neighboring gene LIM domain 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis. Suzuki M, et al. Endocrinology, 2009 Dec. PMID 19837878
  2. Ubiquitin dimers control the hydrolase activity of UCH-L3. Setsuie R, et al. Neurochem Int, 2009 May-Jun. PMID 19154770
  3. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Kurihara LJ, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555633
  4. Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). Dennissen FJ, et al. FEBS Lett, 2011 Aug 19. PMID 21762696
  5. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Larsen CN, et al. Biochemistry, 1998 Mar 10. PMID 9521656

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L3
Names
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
ubiquitin thioesterase L3
NP_001103635.1
XP_038949527.1
XP_063130639.1
XP_063130640.1
XP_063130641.1
XP_063130642.1
XP_063130643.1
XP_063130644.1
XP_063130645.1
XP_063130646.1
XP_063130647.1
XP_063130648.1
XP_063130649.1
XP_063130650.1
XP_063130651.1
XP_063130652.1
XP_063130653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110165.2 → NP_001103635.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

    See identical proteins and their annotated locations for NP_001103635.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q91Y78
    UniProtKB/TrEMBL
    A6KKZ2, D4ABI6, F1LM67
    Related
    ENSRNOP00000012842.5, ENSRNOT00000012842.7
    Conserved Domains (1) summary
    cd09616
    Location:6 → 227
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  2. NM_001428945.1 → NP_001415874.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  3. NM_001428946.1 → NP_001415875.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  4. NM_001428947.1 → NP_001415876.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    84888847..84942095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274573.1 → XP_063130643.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X5

  2. XM_063274569.1 → XP_063130639.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

  3. XM_063274578.1 → XP_063130648.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X10

  4. XM_039093599.2 → XP_038949527.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X15

    UniProtKB/TrEMBL
    A0A8I6AE48, D4ABI6, F1LM67
    Related
    ENSRNOP00000091247.1
    Conserved Domains (1) summary
    cd09616
    Location:6 → 211
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  5. XM_063274577.1 → XP_063130647.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X9

  6. XM_063274579.1 → XP_063130649.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X11

    UniProtKB/TrEMBL
    A0A8J8Y1V7

  7. XM_063274572.1 → XP_063130642.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X4

  8. XM_063274574.1 → XP_063130644.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X6

  9. XM_063274570.1 → XP_063130640.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2

  10. XM_063274582.1 → XP_063130652.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X14

  11. XM_063274581.1 → XP_063130651.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X13

    UniProtKB/TrEMBL
    A6HU77

  12. XM_063274580.1 → XP_063130650.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X12

  13. XM_063274576.1 → XP_063130646.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X8

  14. XM_063274583.1 → XP_063130653.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X16

  15. XM_063274571.1 → XP_063130641.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3

  16. XM_063274575.1 → XP_063130645.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Y78.1 GenPept UniProtKB/Swiss-Prot:Q91Y78

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