Msr1 macrophage scavenger receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Msr1provided by RGD
Official Full Name: macrophage scavenger receptor 1provided by RGD
Primary source: RGD:1564316
See related: Ensembl:ENSRNOG00000012779 AllianceGenome:RGD:1564316
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564316
Summary: Predicted to enable amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in cellular response to organic cyclic compound. Located in cytoplasmic vesicle; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 155.1), Liver (RPKM 138.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (59421250..59507070)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (52717775..52803602)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (56817714..56900025, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta to SR-A, thereby promoting glial phagocytosis of Abeta oligomer in astrocytes.
Title: Activated scavenger receptor A promotes glial internalization of aβ.
The expression of RAGE and Msr1 was significantly down-regulated in the high-AGE diet-fed rats.
Title: Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats.
Scavenger receptor A over-expression is associated with diabetes.
Title: Perindopril attenuates renal tubulointerstitium injury by inhibiting scavenger receptor A over-expression in diabetic rats.
Hook3 interacts with a cytoplasmic domain of scavenger receptor A
Title: The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.

Submit: New GeneRIF Correction

General gene information

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Markers

L04275 (e-PCR)
- UniSTS:159755

UniSTS:496680 (e-PCR)
- UniSTS:496680

Gnb1 (e-PCR), detects polymorphism
- UniSTS:496680

RH127715 (e-PCR)
- UniSTS:211025

AA900898 (e-PCR)
- UniSTS:226203

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macrophage scavenger receptor types I and II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191939.2 → NP_001178868.1 macrophage scavenger receptor types I and II isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D3ZDS2

Related

ENSRNOP00000017339.7, ENSRNOT00000017339.8

Conserved Domains (4) summary

pfam01391
Location:288 → 345

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:353 → 453

SR; Scavenger receptor Cys-rich

pfam00530
Location:358 → 453

SRCR; Scavenger receptor cysteine-rich domain

pfam03523
Location:121 → 169

Macscav_rec; Macrophage scavenger receptor
NM_001411777.1 → NP_001398706.1 macrophage scavenger receptor types I and II isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

59421250..59507070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094773.2 → XP_038950701.1 macrophage scavenger receptor types I and II isoform X1

UniProtKB/TrEMBL

D3ZDS2

Conserved Domains (4) summary

smart00202
Location:408 → 491

SR; Scavenger receptor Cys-rich

pfam01391
Location:343 → 397

Collagen; Collagen triple helix repeat (20 copies)

pfam03523
Location:176 → 224

Macscav_rec; Macrophage scavenger receptor

pfam07426
Location:170 → 277

Dynactin_p22; Dynactin subunit p22