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Cpne2 copine 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498972, updated on 13-Apr-2024

Summary

Official Symbol
Cpne2provided by RGD
Official Full Name
copine 2provided by RGD
Primary source
RGD:1586036
See related
Ensembl:ENSRNOG00000043286 AllianceGenome:RGD:1586036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Orthologous to human CPNE2 (copine 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 66.0), Lung (RPKM 50.2) and 9 other tissues See more
Orthologs
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Genomic context

See Cpne2 in Genome Data Viewer
Location:
19p13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10440245..10477783, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10434277..10472146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10860963..10898970, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene uncharacterized LOC134483687 Neighboring gene uncharacterized LOC134483689 Neighboring gene NLR family, CARD domain containing 5 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC134483688

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NOT located_in clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256466.2NP_001243395.1  copine-2

    See identical proteins and their annotated locations for NP_001243395.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2K0K1, F1M1L9, H1UBM7
    Related
    ENSRNOP00000063507.4, ENSRNOT00000063791.4
    Conserved Domains (3) summary
    cd04047
    Location:155267
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:24141
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:326542
    Copine

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    10440245..10477783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010060019.1 RNA Sequence