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Wtap WT1 associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 499020, updated on 2-May-2024

Summary

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Official Symbol
Wtapprovided by RGD
Official Full Name
WT1 associated proteinprovided by RGD
Primary source
RGD:1563824
See related
Ensembl:ENSRNOG00000019091 AllianceGenome:RGD:1563824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563824
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA methylation and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm; nuclear membrane; and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 300.6), Spleen (RPKM 223.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wtap in Genome Data Viewer
Location:
1q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50070973..50096074)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47665965..47691067)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47942500..47967633)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690969 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 1 Neighboring gene superoxide dismutase 2 Neighboring gene uncharacterized LOC102553528 Neighboring gene acetyl-CoA acetyltransferase, cytosolic-like Neighboring gene acetyl-CoA acetyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling. Wang H, et al. Apoptosis, 2023 Jun. PMID 36894806
  2. SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function. Du Y, et al. Nucleic Acids Res, 2018 Jun 1. PMID 29506078, Free PMC Article
  3. Interactions, localization, and phosphorylation of the m(6)A generating METTL3-METTL14-WTAP complex. Schöller E, et al. RNA, 2018 Apr. PMID 29348140, Free PMC Article
  4. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Liu J, et al. Nat Chem Biol, 2014 Feb. PMID 24316715, Free PMC Article
  5. The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Niksic M, et al. Hum Mol Genet, 2004 Feb 15. PMID 14681305

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling.
    Title: m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing regulator WTAP
Names
Wilms tumor 1 associated protein
Wilms' tumour 1-associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113542.1 → NP_001107014.1  pre-mRNA-splicing regulator WTAP isoform a

    See identical proteins and their annotated locations for NP_001107014.1

    Status: VALIDATED

    Source sequence(s)
    AA900399, CK478322, CO561762, DV714133
    UniProtKB/TrEMBL
    A0A8I5XW36, D3ZPY0
    Related
    ENSRNOP00000025936.5, ENSRNOT00000025936.8
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 222
    Wtap; WTAP/Mum2p family

  2. NM_001113543.1 → NP_001107015.1  pre-mRNA-splicing regulator WTAP isoform b

    See identical proteins and their annotated locations for NP_001107015.1

    Status: VALIDATED

    Source sequence(s)
    BQ202659, CK478322, CV108433, CX570823
    UniProtKB/TrEMBL
    A0A0G2K2U2, A6KP27
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 150
    Wtap; WTAP/Mum2p family

  3. NM_001113544.1 → NP_001107016.1  pre-mRNA-splicing regulator WTAP isoform b

    See identical proteins and their annotated locations for NP_001107016.1

    Status: VALIDATED

    Source sequence(s)
    BQ202659, CB613741, CB613959, CX570823
    UniProtKB/TrEMBL
    A0A0G2K2U2, A6KP27
    Related
    ENSRNOP00000072376.1, ENSRNOT00000079312.2
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 150
    Wtap; WTAP/Mum2p family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    50070973..50096074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270739.1 → XP_063126809.1  pre-mRNA-splicing regulator WTAP isoform X3

  2. XM_006227892.5 → XP_006227954.1  pre-mRNA-splicing regulator WTAP isoform X1

    See identical proteins and their annotated locations for XP_006227954.1

    UniProtKB/TrEMBL
    A0A8I5XW36, D3ZPY0
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 222
    Wtap; WTAP/Mum2p family

  3. XM_039086894.2 → XP_038942822.1  pre-mRNA-splicing regulator WTAP isoform X3

    UniProtKB/TrEMBL
    A6KP27
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 150
    Wtap; WTAP/Mum2p family

  4. XM_006227893.4 → XP_006227955.1  pre-mRNA-splicing regulator WTAP isoform X1

    See identical proteins and their annotated locations for XP_006227955.1

    UniProtKB/TrEMBL
    A0A8I5XW36, D3ZPY0
    Related
    ENSRNOP00000077397.1
    Conserved Domains (1) summary
    pfam17098
    Location:68 → 222
    Wtap; WTAP/Mum2p family

  5. XM_063270747.1 → XP_063126817.1  pre-mRNA-splicing regulator WTAP isoform X3

  6. XM_039086893.2 → XP_038942821.1  pre-mRNA-splicing regulator WTAP isoform X2

    UniProtKB/TrEMBL
    A6KP29
    Conserved Domains (1) summary
    pfam17098
    Location:1 → 65
    Wtap; WTAP/Mum2p family

  7. XM_039086890.2 → XP_038942818.1  pre-mRNA-splicing regulator WTAP isoform X2

    UniProtKB/TrEMBL
    A6KP29
    Conserved Domains (1) summary
    pfam17098
    Location:1 → 65
    Wtap; WTAP/Mum2p family
Nucleotide Protein Strain
Heading Accession and Version

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