U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pum3 pumilio RNA-binding family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499339, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pum3provided by RGD
Official Full Name
pumilio RNA-binding family member 3provided by RGD
Primary source
RGD:1564753
See related
Ensembl:ENSRNOG00000012574 AllianceGenome:RGD:1564753
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of protein ADP-ribosylation and regulation of translation. Predicted to be located in chromosome; endoplasmic reticulum; and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human PUM3 (pumilio RNA binding family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 62.4), Adrenal (RPKM 57.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q52
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (234483482..234527718, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (225074332..225113995, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (245476400..245517081, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100010 Neighboring gene uncharacterized LOC134485215 Neighboring gene very low density lipoprotein receptor Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene uncharacterized LOC102555808 Neighboring gene uncharacterized LOC102555989 Neighboring gene uncharacterized LOC134485216

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress. Chang HY, et al. Cancer Res, 2011 Feb 1. PMID 21266351
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  3. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pumilio homolog 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025036.1 → NP_001020207.1  pumilio homolog 3

    See identical proteins and their annotated locations for NP_001020207.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092579
    UniProtKB/Swiss-Prot
    Q4G054, Q562C7
    UniProtKB/TrEMBL
    A0A8L2QIX0
    Related
    ENSRNOP00000034834.4, ENSRNOT00000033724.5
    Conserved Domains (2) summary
    cl21719
    Location:181 → 441
    Pumilio; Pumilio-family RNA binding domain
    pfam08144
    Location:433 → 570
    CPL; CPL (NUC119) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    234483482..234527718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271704.1 → XP_063127774.1  pumilio homolog 3 isoform X1

  2. XM_063271710.1 → XP_063127780.1  pumilio homolog 3 isoform X2

    UniProtKB/Swiss-Prot
    Q4G054, Q562C7

  3. XM_063271708.1 → XP_063127778.1  pumilio homolog 3 isoform X1

  4. XM_063271714.1 → XP_063127784.1  pumilio homolog 3 isoform X2

    UniProtKB/Swiss-Prot
    Q4G054, Q562C7

  5. XM_063271722.1 → XP_063127792.1  pumilio homolog 3 isoform X4

  6. XM_063271726.1 → XP_063127796.1  pumilio homolog 3 isoform X5

  7. XM_063271719.1 → XP_063127789.1  pumilio homolog 3 isoform X3

RNA

  1. XR_010056425.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q562C7.1 GenPept UniProtKB/Swiss-Prot:Q562C7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous