Calhm1 calcium homeostasis modulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Calhm1provided by RGD
Official Full Name: calcium homeostasis modulator 1provided by RGD
Primary source: RGD:1564891
See related: Ensembl:ENSRNOG00000030682 AllianceGenome:RGD:1564891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam26c; RGD1564891
Summary: Predicted to enable calcium activated cation channel activity; identical protein binding activity; and voltage-gated calcium channel activity. Predicted to be involved in several processes, including ATP transport; protein complex oligomerization; and sensory perception of taste. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human CALHM1 (calcium homeostasis modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1.7), Testes (RPKM 0.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q54

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255971606..255974325, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (246030269..246032988, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266916312..266919031, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Control of astrocytic Ca[2+] signaling by nitric oxide-dependent S-nitrosylation of Ca[2+] homeostasis modulator 1 channels.
Title: Control of astrocytic Ca(2+) signaling by nitric oxide-dependent S-nitrosylation of Ca(2+) homeostasis modulator 1 channels.
CALHM1 was increased in painful diabetic neuropathy compared with controls.
Title: miR-9 Mediates CALHM1-Activated ATP-P2X7R Signal in Painful Diabetic Neuropathy Rats.
findings indicate that communication between salt-detecting cells and nerve endings might involve ATP release by CALMH1 channels.
Title: Calcium Homeostasis Modulator 1-Like Currents in Rat Fungiform Taste Cells Expressing Amiloride-Sensitive Sodium Currents.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP export	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of umami taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium homeostasis modulator protein 1

Names: family with sequence similarity 26, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.