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Prmt2 protein arginine methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499420, updated on 11-Apr-2024

Summary

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Symbol
Prmt2provided by RGD
Full Name
protein arginine methyltransferase 2provided by RGD
Primary source
RGD:1565519
See related
Ensembl:ENSRNOG00000001297 AllianceGenome:RGD:1565519
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hrmt1l1
Summary
Predicted to enable several functions, including beta-catenin binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Biomarker of asthma. Orthologous to human PRMT2 (protein arginine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 49.6), Thymus (RPKM 49.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prmt2 in Genome Data Viewer
Location:
20p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12391388..12420096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12394748..12420643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13154513..13212613)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene disco-interacting protein 2 homolog A Neighboring gene uncharacterized LOC134483887 Neighboring gene U6 spliceosomal RNA Neighboring gene S100 calcium binding protein B Neighboring gene microRNA 678 Neighboring gene solute carrier family 5 member 4 Neighboring gene solute carrier family 5 (neutral amino acid transporters, system A), member 4b Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Iwasaki H, et al. Circ Res, 2010 Oct 15. PMID 20798359, Free PMC Article
  2. beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Blythe SA, et al. Dev Cell, 2010 Aug 17. PMID 20708585, Free PMC Article
  3. PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. Meyer R, et al. J Steroid Biochem Mol Biol, 2007 Oct. PMID 17587566
  4. [Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma]. Sun QZ, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2010 Apr. PMID 20423833
  5. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Kzhyshkowska J, et al. Biochem J, 2001 Sep 1. PMID 11513728, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear progesterone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein arginine N-methyltransferase 2
Names
HMT1 hnRNP methyltransferase-like 1
NP_001020315.1
XP_038954937.1
XP_038954938.1
XP_063135531.1
XP_063135532.1
XP_063135533.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025144.1 → NP_001020315.1  protein arginine N-methyltransferase 2

    See identical proteins and their annotated locations for NP_001020315.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079112
    UniProtKB/TrEMBL
    A0A9K3Y6N8, F1LMD8, Q6AYB9
    Related
    ENSRNOP00000039976.3, ENSRNOT00000050531.4
    Conserved Domains (2) summary
    cd02440
    Location:153 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:46 → 98
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12391388..12420096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279461.1 → XP_063135531.1  protein arginine N-methyltransferase 2 isoform X1

  2. XM_063279462.1 → XP_063135532.1  protein arginine N-methyltransferase 2 isoform X1

  3. XM_039099010.2 → XP_038954938.1  protein arginine N-methyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y6N8, F1LMD8, Q6AYB9
    Conserved Domains (2) summary
    cd02440
    Location:153 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:46 → 98
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2

  4. XM_039099009.2 → XP_038954937.1  protein arginine N-methyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y6N8, F1LMD8, Q6AYB9
    Conserved Domains (2) summary
    cd02440
    Location:153 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:46 → 98
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2

  5. XM_063279463.1 → XP_063135533.1  protein arginine N-methyltransferase 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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