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Tmem174 transmembrane protein 174 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499516, updated on 3-Apr-2024

Summary

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Official Symbol
Tmem174provided by RGD
Official Full Name
transmembrane protein 174provided by RGD
Primary source
RGD:1561129
See related
Ensembl:ENSRNOG00000015472 AllianceGenome:RGD:1561129
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human TMEM174 (transmembrane protein 174). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 935.3) See more
Orthologs
human mouse all
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Genomic context

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See Tmem174 in Genome Data Viewer
Location:
2q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31695051..31738819, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29992070..29993601, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (28748706..28750237, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120100554 Neighboring gene uncharacterized LOC134485825 Neighboring gene uncharacterized LOC108349927

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification. Miyazaki-Anzai S, et al. J Am Soc Nephrol, 2022 Aug. PMID 35459732, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 174

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024298.1 → NP_001019469.1  transmembrane protein 174

    See identical proteins and their annotated locations for NP_001019469.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079357
    UniProtKB/Swiss-Prot
    Q68FU0
    Related
    ENSRNOP00000020879.3, ENSRNOT00000020879.6
    Conserved Domains (1) summary
    pfam15029
    Location:10 → 241
    DUF4526; Protein of unknown function (DUF4526)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    31695051..31738819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282345.1 → XP_063138415.1  transmembrane protein 174 isoform X2

    UniProtKB/Swiss-Prot
    Q68FU0

  2. XM_063282344.1 → XP_063138414.1  transmembrane protein 174 isoform X1

    UniProtKB/TrEMBL
    A6I546
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FU0.1 GenPept UniProtKB/Swiss-Prot:Q68FU0

Gene LinkOut

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