Ubr1 ubiquitin protein ligase E3 component n-recognin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubr1provided by RGD
Official Full Name: ubiquitin protein ligase E3 component n-recognin 1provided by RGD
Primary source: RGD:1562326
See related: Ensembl:ENSRNOG00000037207 AllianceGenome:RGD:1562326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562326
Summary: Predicted to enable leucine binding activity and ubiquitin-protein transferase activity. Predicted to be involved in cellular response to leucine and negative regulation of TOR signaling. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 194.3), Lung (RPKM 179.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128265160..128377830, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (107813721..107921701, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (112800557..112910038, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
Title: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE102818 (e-PCR)
- UniSTS:244370

BF387584 (e-PCR)
- UniSTS:261019

BF405998 (e-PCR)
- UniSTS:247982

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-leucine binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase UBR1

NP_001171543.1

EC 2.3.2.27

XP_063140437.1

EC 2.3.2.27

XP_063140438.1

EC 2.3.2.27

XP_063140439.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001178072.2 → NP_001171543.1 E3 ubiquitin-protein ligase UBR1

See identical proteins and their annotated locations for NP_001171543.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZZN6, D5MTG9

Related

ENSRNOP00000084477.1, ENSRNOT00000108697.1

Conserved Domains (2) summary

pfam02207
Location:99 → 166

zf-UBR; Putative zinc finger in N-recognin (UBR box)

pfam02617
Location:221 → 301

ClpS; ATP-dependent Clp protease adaptor protein ClpS