Tgif2 TGFB-induced factor homeobox 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgif2provided by RGD
Official Full Name: TGFB-induced factor homeobox 2provided by RGD
Primary source: RGD:1560115
See related: Ensembl:ENSRNOG00000042374 AllianceGenome:RGD:1560115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tgif2l1; RGD1560115; RGD1564927
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nodal signaling pathway; positive regulation of neuron differentiation; and regulation of gastrulation. Predicted to be located in centrosome and nucleoplasm. Orthologous to several human genes including TGIF2-RAB5IF (TGIF2-RAB5IF readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 35.3), Adrenal (RPKM 28.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (165791101..165808669)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (145333152..145348599)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (152906961..152924380)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-34a can alleviate steroid-induced avascular necrosis of femoral head through targeting Tgif2
Title: MicroRNA-34a alleviates steroid-induced avascular necrosis of femoral head by targeting Tgif2 through OPG/RANK/RANKL signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

Tgif2 (e-PCR), detects polymorphism
- UniSTS:469810

UniSTS:469811 (e-PCR)
- UniSTS:469811

Tgif2 (e-PCR), detects polymorphism
- UniSTS:469811

Tgif2 (e-PCR), detects polymorphism
- UniSTS:547379

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nodal signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein TGIF2

Names: TGFB-induced factor homeobox 2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.