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Dsn1 DSN1 component of MIS12 kinetochore complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 499933, updated on 2-May-2024

Summary

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Official Symbol
Dsn1provided by RGD
Official Full Name
DSN1 component of MIS12 kinetochore complexprovided by RGD
Primary source
RGD:1565179
See related
Ensembl:ENSRNOG00000006236 AllianceGenome:RGD:1565179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mitotic sister chromatid segregation. Predicted to be located in cytosol; kinetochore; and nuclear lumen. Predicted to be part of nuclear MIS12/MIND complex. Orthologous to human DSN1 (DSN1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 69.3), Spleen (RPKM 51.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166072775..166089029, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145652741..145668025, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (153101020..153115326, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein NDRG3-like Neighboring gene NDRG family member 3 Neighboring gene microtubule crosslinking factor 2 Neighboring gene TBC/LysM-associated domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma. Sun C, et al. Hum Pathol, 2018 Nov. PMID 30136646
  2. Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Chuang TP, et al. Oncotarget, 2016 Jul 19. PMID 27329586, Free PMC Article
  3. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. Kline SL, et al. J Cell Biol, 2006 Apr 10. PMID 16585270, Free PMC Article
  4. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Cheeseman IM, et al. Genes Dev, 2004 Sep 15. PMID 15371340, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC116180

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MIS12/MIND type complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinetochore-associated protein DSN1 homolog
Names
DSN1 homolog, MIS12 kinetochore complex component
DSN1, MIND kinetochore complex component, homolog
DSN1, MIS12 kinetochore complex component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025768.2 → NP_001020939.1  kinetochore-associated protein DSN1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001020939.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ADJ6, A6JWQ5, F7F478, Q4V7C0
    Related
    ENSRNOP00000008255.4, ENSRNOT00000008254.7
    Conserved Domains (1) summary
    pfam08202
    Location:76 → 345
    MIS13; Mis12-Mtw1 protein family

  2. NM_001428683.1 → NP_001415612.1  kinetochore-associated protein DSN1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JWQ5, F7F478, Q4V7C0

  3. NM_001428684.1 → NP_001415613.1  kinetochore-associated protein DSN1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001428685.1 → NP_001415614.1  kinetochore-associated protein DSN1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AFX7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    166072775..166089029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284393.1 → XP_063140463.1  kinetochore-associated protein DSN1 homolog isoform X3

  2. XM_039105707.2 → XP_038961635.1  kinetochore-associated protein DSN1 homolog isoform X5

    Conserved Domains (1) summary
    pfam08202
    Location:9 → 272
    MIS13; Mis12-Mtw1 protein family

  3. XM_063284394.1 → XP_063140464.1  kinetochore-associated protein DSN1 homolog isoform X5

  4. XM_006235376.5 → XP_006235438.1  kinetochore-associated protein DSN1 homolog isoform X2

    Conserved Domains (1) summary
    pfam08202
    Location:76 → 345
    MIS13; Mis12-Mtw1 protein family

  5. XM_039105706.2 → XP_038961634.1  kinetochore-associated protein DSN1 homolog isoform X4

    Conserved Domains (1) summary
    pfam08202
    Location:11 → 274
    MIS13; Mis12-Mtw1 protein family

  6. XM_006235375.4 → XP_006235437.1  kinetochore-associated protein DSN1 homolog isoform X1

    Related
    ENSRNOP00000091670.1
    Conserved Domains (1) summary
    pfam08202
    Location:78 → 347
    MIS13; Mis12-Mtw1 protein family

  7. XM_063284395.1 → XP_063140465.1  kinetochore-associated protein DSN1 homolog isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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