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Agbl3 AGBL carboxypeptidase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500076, updated on 6-Jun-2024

Summary

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Official Symbol
Agbl3provided by RGD
Official Full Name
AGBL carboxypeptidase 3provided by RGD
Primary source
RGD:1561995
See related
Ensembl:ENSRNOG00000010397 AllianceGenome:RGD:1561995
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561995
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Predicted to be located in cytosol. Orthologous to human AGBL3 (AGBL carboxypeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 41.0), Kidney (RPKM 30.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Agbl3 in Genome Data Viewer
Location:
4q22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64416139..64498987)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63448789..63535538)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62293158..62377740)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene bisphosphoglycerate mutase Neighboring gene caldesmon 1 Neighboring gene uncharacterized LOC120102254 Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ Neighboring gene WD repeat domain 91

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. Rodriguez de la Vega M, et al. FASEB J, 2007 Mar. PMID 17244817
  2. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytosolic carboxypeptidase 3
Names
ATP/GTP binding protein-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    64416139..64498987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592971.3 → XP_017448460.1  cytosolic carboxypeptidase 3 isoform X1

    UniProtKB/TrEMBL
    D3ZNU5
    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  2. XM_063286921.1 → XP_063142991.1  cytosolic carboxypeptidase 3 isoform X2

  3. XM_063286927.1 → XP_063142997.1  cytosolic carboxypeptidase 3 isoform X11

  4. XM_039108622.2 → XP_038964550.1  cytosolic carboxypeptidase 3 isoform X1

    UniProtKB/TrEMBL
    D3ZNU5
    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  5. XM_063286926.1 → XP_063142996.1  cytosolic carboxypeptidase 3 isoform X10

  6. XM_006236277.5 → XP_006236339.1  cytosolic carboxypeptidase 3 isoform X1

    See identical proteins and their annotated locations for XP_006236339.1

    UniProtKB/TrEMBL
    D3ZNU5
    Related
    ENSRNOP00000034021.6
    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  7. XM_039108623.2 → XP_038964551.1  cytosolic carboxypeptidase 3 isoform X4

    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  8. XM_063286928.1 → XP_063142998.1  cytosolic carboxypeptidase 3 isoform X12

  9. XM_039108624.2 → XP_038964552.1  cytosolic carboxypeptidase 3 isoform X5

    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  10. XM_039108626.2 → XP_038964554.1  cytosolic carboxypeptidase 3 isoform X7

    UniProtKB/TrEMBL
    A6IEM6
    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  11. XM_063286923.1 → XP_063142993.1  cytosolic carboxypeptidase 3 isoform X6

    UniProtKB/TrEMBL
    A6IEM6

  12. XM_063286925.1 → XP_063142995.1  cytosolic carboxypeptidase 3 isoform X9

    UniProtKB/TrEMBL
    A6IEM6

  13. XM_063286924.1 → XP_063142994.1  cytosolic carboxypeptidase 3 isoform X8

    UniProtKB/TrEMBL
    A6IEM6

  14. XM_063286922.1 → XP_063142992.1  cytosolic carboxypeptidase 3 isoform X3

  15. XM_039108627.2 → XP_038964555.1  cytosolic carboxypeptidase 3 isoform X8

    UniProtKB/TrEMBL
    A6IEM6
    Conserved Domains (2) summary
    cd06907
    Location:319 → 571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171 → 297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

RNA

  1. XR_010066130.1 RNA Sequence

  2. XR_005503510.2 RNA Sequence

  3. XR_010066132.1 RNA Sequence

  4. XR_005503511.2 RNA Sequence

  5. XR_010066131.1 RNA Sequence

Nucleotide Protein Strain
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