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ORC5 origin recognition complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 5001, updated on 5-Jan-2025

Summary

Official Symbol
ORC5provided by HGNC
Official Full Name
origin recognition complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:8491
See related
Ensembl:ENSG00000164815 MIM:602331; AllianceGenome:HGNC:8491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC5L; ORC5P; ORC5T; PPP1R117
Summary
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

See ORC5 in Genome Data Viewer
Location:
7q22.1-q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (104126341..104208013, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (105440576..105522271, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (103766788..103848461, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene SLC26A5 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:103130126-103131325 Neighboring gene uncharacterized LOC105375435 Neighboring gene Sharpr-MPRA regulatory region 15155 Neighboring gene RN7SK pseudogene 86 Neighboring gene reelin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:103301048-103302247 Neighboring gene Sharpr-MPRA regulatory region 11588 Neighboring gene MPRA-validated peak6667 silencer Neighboring gene Sharpr-MPRA regulatory region 1232 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3907 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:103691916-103692125 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:103765716-103765879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26445 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:103904410-103905609 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:103916337-103917536 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:104001319-104001836 Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:104169841-104171040 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:104190573-104191772 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 6 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:104412644-104413408 Neighboring gene LHFPL3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables DNA replication origin binding  
enables nucleotide binding PubMed 
enables protein binding PubMed 

General protein information

Preferred Names
origin recognition complex subunit 5
Names
protein phosphatase 1, regulatory subunit 117

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029899.2 RefSeqGene

    Range
    5000..86672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002553.4NP_002544.1  origin recognition complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_002544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007393, AK223361, BC023652
    Consensus CDS
    CCDS5734.1
    UniProtKB/Swiss-Prot
    A4D0P8, O43913, O60590, O95268
    UniProtKB/TrEMBL
    A4D0P7, Q53FC8
    Related
    ENSP00000297431.4, ENST00000297431.9
    Conserved Domains (2) summary
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177431
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
  2. NM_181747.4NP_859531.1  origin recognition complex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_859531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exon, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC007393, AF081459, AK223361
    Consensus CDS
    CCDS47681.1
    UniProtKB/Swiss-Prot
    O43913
    UniProtKB/TrEMBL
    Q53FC8
    Related
    ENSP00000395747.2, ENST00000447452.6
    Conserved Domains (2) summary
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177290
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    104126341..104208013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420431.1XP_047276387.1  origin recognition complex subunit 5 isoform X2

  2. XM_011516273.4XP_011514575.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (3) summary
    COG1474
    Location:11191
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177228
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    105440576..105522271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358314.1XP_054214289.1  origin recognition complex subunit 5 isoform X2

  2. XM_054358313.1XP_054214288.1  origin recognition complex subunit 5 isoform X1

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