Zfp398 zinc finger protein 398 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp398provided by RGD
Official Full Name: zinc finger protein 398provided by RGD
Primary source: RGD:1562129
See related: Ensembl:ENSRNOG00000006703 AllianceGenome:RGD:1562129
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562129
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZNF398 (zinc finger protein 398). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 60.7), Brain (RPKM 56.3) and 9 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (78180620..78214367)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (76849672..76881075)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (77519018..77546517)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: zinc finger protein 398

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109230.1 → NP_001102700.1 zinc finger protein 398

See identical proteins and their annotated locations for NP_001102700.1

Status: PROVISIONAL

Source sequence(s)

CH474011

UniProtKB/TrEMBL

A6K0D2, D3ZGH2

Related

ENSRNOP00000008743.5, ENSRNOT00000008743.7

Conserved Domains (3) summary

smart00349
Location:143 → 203

KRAB; krueppel associated box

COG5048
Location:344 → 588

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:486 → 506

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

78180620..78214367

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286507.1 → XP_063142577.1 zinc finger protein 398 isoform X1

UniProtKB/TrEMBL

A0A8I6A350
XM_008762904.4 → XP_008761126.1 zinc finger protein 398 isoform X2

UniProtKB/TrEMBL

A0A8I6ACN4

Related

ENSRNOP00000090514.1

Conserved Domains (6) summary

cd07765
Location:11 → 50

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

smart00349
Location:11 → 71

KRAB; krueppel associated box

COG5048
Location:212 → 456

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:354 → 374

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:408 → 430

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:422 → 447

zf-H2C2_2; Zinc-finger double domain
XM_039108122.2 → XP_038964050.1 zinc finger protein 398 isoform X4

Conserved Domains (2) summary

COG5048
Location:173 → 417

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:315 → 335

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_008762905.4 → XP_008761127.1 zinc finger protein 398 isoform X3

Conserved Domains (6) summary

cd07765
Location:4 → 43

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

smart00349
Location:4 → 64

KRAB; krueppel associated box

COG5048
Location:205 → 449

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:347 → 367

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:401 → 423

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:415 → 440

zf-H2C2_2; Zinc-finger double domain