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Creb5 cAMP responsive element binding protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500131, updated on 5-Mar-2024

Summary

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Official Symbol
Creb5provided by RGD
Official Full Name
cAMP responsive element binding protein 5provided by RGD
Primary source
RGD:1566107
See related
Ensembl:ENSRNOG00000008622 AllianceGenome:RGD:1566107
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566107
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; and white fat cell differentiation. Predicted to act upstream of or within adipose tissue development; fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 32.7), Muscle (RPKM 23.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (83723587..84124786)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (82393091..82794320)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (83390782..83840356)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene creatine kinase, mitochondrial 1, pseudogene 1 Neighboring gene uncharacterized LOC120102281 Neighboring gene uncharacterized LOC134486769 Neighboring gene TLR4 interactor with leucine-rich repeats

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. Zu YL, et al. Oncogene, 1993 Oct. PMID 8378084
  2. Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. Deng B, et al. Cell Biosci, 2014. PMID 25105010, Free PMC Article
  3. The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Maekawa T, et al. Mol Cell Biol, 2010 Feb. PMID 19948881, Free PMC Article
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclic AMP-responsive element-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134621.1 → NP_001128093.1  cyclic AMP-responsive element-binding protein 5

    See identical proteins and their annotated locations for NP_001128093.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474011
    UniProtKB/TrEMBL
    A6K0T7, D3ZBH0
    Related
    ENSRNOP00000036595.4, ENSRNOT00000031365.6
    Conserved Domains (1) summary
    cd14687
    Location:430 → 489
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    83723587..84124786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108137.2 → XP_038964065.1  cyclic AMP-responsive element-binding protein 5 isoform X6

  2. XM_039108135.2 → XP_038964063.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQI5
    Related
    ENSRNOP00000079273.1
    Conserved Domains (1) summary
    cd14687
    Location:377 → 436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  3. XM_039108134.2 → XP_038964062.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    Conserved Domains (1) summary
    cd14687
    Location:421 → 480
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  4. XM_017592796.3 → XP_017448285.1  cyclic AMP-responsive element-binding protein 5 isoform X3

  5. XM_008762908.4 → XP_008761130.1  cyclic AMP-responsive element-binding protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K5F0
    Related
    ENSRNOP00000073400.1
    Conserved Domains (1) summary
    cd14687
    Location:238 → 297
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  6. XM_039108136.2 → XP_038964064.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    Conserved Domains (1) summary
    cd14687
    Location:263 → 322
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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