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Cecr2 CECR2, histone acetyl-lysine reader [ Rattus norvegicus (Norway rat) ]

Gene ID: 500308, updated on 3-Apr-2024

Summary

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Official Symbol
Cecr2provided by RGD
Official Full Name
CECR2, histone acetyl-lysine readerprovided by RGD
Primary source
RGD:1564182
See related
Ensembl:ENSRNOG00000011566 AllianceGenome:RGD:1564182
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564182
Summary
Predicted to be involved in execution phase of apoptosis and single fertilization. Predicted to act upstream of or within chromatin remodeling; inner ear development; and primary neural tube formation. Predicted to be located in euchromatin and nucleus. Predicted to be part of CERF complex. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 43.0), Heart (RPKM 37.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cecr2 in Genome Data Viewer
Location:
4q42
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155562576..155670253)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153890310..153998078)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153217521..153327153)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene haloacid dehalogenase like hydrolase domain containing 5 Neighboring gene uncharacterized LOC108350753 Neighboring gene solute carrier family 25 member 18 Neighboring gene ATPase H+ transporting V1 subunit E1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. Banting GS, et al. Hum Mol Genet, 2005 Feb 15. PMID 15640247
  2. Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes. Kooistra MK, et al. Physiol Genomics, 2012 Jan 18. PMID 22045912
  3. Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Fairbridge NA, et al. Birth Defects Res A Clin Mol Teratol, 2010 Aug. PMID 20589882
  4. Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dawe CE, et al. Dev Dyn, 2011 Feb. PMID 21246654
  5. Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. Liu L, et al. In Vitro Cell Dev Biol Anim, 2002 Nov-Dec. PMID 12762840, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP-dependent chromatin remodeler activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cochlea development ISO
Inferred from Sequence Orthology
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural fold formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single fertilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CERF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CERF complex ISO
Inferred from Sequence Orthology
more info
  
part_of ISWI-type complex ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cat eye syndrome critical region protein 2
Names
cat eye syndrome chromosome region, candidate 2 homolog
cat eye syndrome chromosome region, candidate 2 homolog-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191977.1 → NP_001178906.1  cat eye syndrome critical region protein 2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000081411.1, ENSRNOT00000104130.1
    Conserved Domains (2) summary
    cd05509
    Location:418 → 518
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam15614
    Location:244 → 284
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    155562576..155670253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763251.4 → XP_008761473.1  cat eye syndrome critical region protein 2 isoform X1

    UniProtKB/TrEMBL
    F1LYI0
    Related
    ENSRNOP00000015499.6
    Conserved Domains (2) summary
    cd05509
    Location:418 → 518
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam15614
    Location:244 → 284
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

  2. XM_008763252.4 → XP_008761474.1  cat eye syndrome critical region protein 2 isoform X2

    Conserved Domains (2) summary
    cd05509
    Location:418 → 518
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam15614
    Location:244 → 284
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

  3. XM_039108208.2 → XP_038964136.1  cat eye syndrome critical region protein 2 isoform X3

    Conserved Domains (2) summary
    cd05509
    Location:390 → 490
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    PHA03247
    Location:514 → 1005
    PHA03247; large tegument protein UL36; Provisional

  4. XM_063286570.1 → XP_063142640.1  cat eye syndrome critical region protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRX4

  5. XM_039108209.2 → XP_038964137.1  cat eye syndrome critical region protein 2 isoform X5

    Conserved Domains (2) summary
    cd05509
    Location:418 → 518
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam03154
    Location:613 → 860
    Atrophin-1; Atrophin-1 family

  6. XM_039108210.2 → XP_038964138.1  cat eye syndrome critical region protein 2 isoform X5

    Conserved Domains (2) summary
    cd05509
    Location:418 → 518
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam03154
    Location:613 → 860
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

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