U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Esrp1 epithelial splicing regulatory protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500409, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Esrp1provided by RGD
Official Full Name
epithelial splicing regulatory protein 1provided by RGD
Primary source
RGD:1560481
See related
Ensembl:ENSRNOG00000008184 AllianceGenome:RGD:1560481
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560481
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing and regulation of inner ear auditory receptor cell fate specification. Predicted to act upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nuclear body. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 53.7), Kidney (RPKM 28.9) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Esrp1 in Genome Data Viewer
Location:
5q13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (29224831..29279381, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (24427611..24482157, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (24576988..24631758, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cyclin E2 Neighboring gene integrator complex subunit 8 Neighboring gene dpy-19 like 4 Neighboring gene ribosomal protein S23, pseudogene 1 Neighboring gene enolase 1, pseudogene 21 Neighboring gene ribosomal protein L24 like 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Epithelial splicing regulator protein 1 and alternative splicing in somatotroph adenomas. Lekva T, et al. Endocrinology, 2013 Sep. PMID 23825128
  2. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Warzecha CC, et al. Mol Cell, 2009 Mar 13. PMID 19285943, Free PMC Article
  3. ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Rohacek AM, et al. Dev Cell, 2017 Nov 6. PMID 29107558, Free PMC Article
  4. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of inner ear auditory receptor cell fate specification ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inner ear auditory receptor cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
epithelial splicing regulatory protein 1
Names
RNA-binding motif protein 35A
RNA-binding protein 35A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127564.2 → NP_001121036.2  epithelial splicing regulatory protein 1

    See identical proteins and their annotated locations for NP_001121036.2

    Status: PROVISIONAL

    Source sequence(s)
    BC166735
    UniProtKB/Swiss-Prot
    B2RYD2
    Related
    ENSRNOP00000095508.1, ENSRNOT00000110297.1
    Conserved Domains (6) summary
    COG0724
    Location:285 → 473
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12736
    Location:221 → 305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310 → 418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444 → 524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29 → 168
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:630 → 658
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    29224831..29279381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288192.1 → XP_063144262.1  epithelial splicing regulatory protein 1 isoform X7

  2. XM_063288193.1 → XP_063144263.1  epithelial splicing regulatory protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6APB2, A6JFT3

  3. XM_006237878.5 → XP_006237940.1  epithelial splicing regulatory protein 1 isoform X4

    UniProtKB/Swiss-Prot
    B2RYD2
    UniProtKB/TrEMBL
    A0A8L2QVS8
    Related
    ENSRNOP00000063046.2
    Conserved Domains (6) summary
    COG0724
    Location:285 → 473
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12736
    Location:221 → 305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310 → 418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444 → 524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29 → 168
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:634 → 662
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_006237880.5 → XP_006237942.1  epithelial splicing regulatory protein 1 isoform X6

    UniProtKB/Swiss-Prot
    B2RYD2
    Conserved Domains (5) summary
    COG0724
    Location:285 → 473
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12736
    Location:221 → 305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310 → 418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444 → 524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29 → 168
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  5. XM_063288195.1 → XP_063144265.1  epithelial splicing regulatory protein 1 isoform X10

  6. XM_063288196.1 → XP_063144266.1  epithelial splicing regulatory protein 1 isoform X11

  7. XM_063288190.1 → XP_063144260.1  epithelial splicing regulatory protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LP81

  8. XM_063288191.1 → XP_063144261.1  epithelial splicing regulatory protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AFU1

  9. XM_039110538.2 → XP_038966466.1  epithelial splicing regulatory protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RYD2
    Conserved Domains (4) summary
    cd12739
    Location:309 → 419
    RRM2_ESRP1; RNA recognition motif 2 (RRM2) found in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:443 → 523
    RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29 → 168
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:216 → 307
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_006237877.5 → XP_006237939.1  epithelial splicing regulatory protein 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RYD2
    Conserved Domains (6) summary
    COG0724
    Location:285 → 473
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12736
    Location:221 → 305
    RRM1_ESRP1; RNA recognition motif 1 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12739
    Location:310 → 418
    RRM2_ESRP1; RNA recognition motif 2 in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:444 → 524
    RRM3_ESRP1_ESRP2; RNA recognition motif in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl10012
    Location:29 → 168
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:630 → 668
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_039110539.2 → XP_038966467.1  epithelial splicing regulatory protein 1 isoform X9

    Conserved Domains (3) summary
    cd12739
    Location:138 → 248
    RRM2_ESRP1; RNA recognition motif 2 (RRM2) found in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:272 → 352
    RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl17169
    Location:44 → 136
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. XM_039110540.2 → XP_038966468.1  epithelial splicing regulatory protein 1 isoform X9

    Conserved Domains (3) summary
    cd12739
    Location:138 → 248
    RRM2_ESRP1; RNA recognition motif 2 (RRM2) found in epithelial splicing regulatory protein 1 (ESRP1) and similar proteins
    cd12742
    Location:272 → 352
    RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
    cl17169
    Location:44 → 136
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RYD2.2 GenPept UniProtKB/Swiss-Prot:B2RYD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous