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Zbtb8b zinc finger and BTB domain containing 8b [ Rattus norvegicus (Norway rat) ]

Gene ID: 500553, updated on 11-Apr-2024

Summary

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Official Symbol
Zbtb8bprovided by RGD
Official Full Name
zinc finger and BTB domain containing 8bprovided by RGD
Primary source
RGD:1562327
See related
Ensembl:ENSRNOG00000026898 AllianceGenome:RGD:1562327
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zbtb8; Zbtb8l; RGD1562327
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB8B (zinc finger and BTB domain containing 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 17.5), Liver (RPKM 4.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb8b in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147046150..147065961, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141765925..141781619, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147628566..147644209, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene diablo, IAP-binding mitochondrial protein like 1 Neighboring gene ribosomal protein L35A, pseudogene 3 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 2 Neighboring gene BSD domain containing 1 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene family with sequence similarity 229, member A Neighboring gene testis-specific serine kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 8B
Names
zinc finger and BTB domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109265.1 → NP_001102735.1  zinc finger and BTB domain-containing protein 8B

    See identical proteins and their annotated locations for NP_001102735.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6ISI8
    Conserved Domains (4) summary
    smart00225
    Location:25 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:331 → 351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 118
    BTB; BTB/POZ domain
    pfam13465
    Location:344 → 368
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    147046150..147065961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238967.4 → XP_006239029.1  zinc finger and BTB domain-containing protein 8B isoform X1

    UniProtKB/TrEMBL
    D3ZLP0
    Related
    ENSRNOP00000034741.5
    Conserved Domains (5) summary
    smart00225
    Location:58 → 155
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:357 → 431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:47 → 151
    BTB; BTB/POZ domain
    pfam13465
    Location:377 → 401
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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