U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pax7 paired box 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500574, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Pax7provided by RGD
Official Full Name
paired box 7provided by RGD
Primary source
RGD:1564360
See related
Ensembl:ENSRNOG00000018739 AllianceGenome:RGD:1564360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564360
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of nitrogen compound metabolic process. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 17.9) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pax7 in Genome Data Viewer
Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (157279623..157381188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151996368..152098023, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (158211001..158313510, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 4 family, member A1 Neighboring gene taste 1 receptor member 2 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like Neighboring gene kelch domain containing 7A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. [Pax7 and depletion of satellite cell pool in prolonged denervated skeletal muscles of adult rats]. Liao H, et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2009 Jan. PMID 19192888
  2. The expression patterns of Pax7 in satellite cells during overload-induced rat adult skeletal muscle hypertrophy. Ishido M, et al. Acta Physiol (Oxf), 2009 Apr. PMID 18808442
  3. Pax7 expression in the adult rat superior colliculus following optic nerve injury. Thomas MG, et al. Neuroreport, 2007 Jan 22. PMID 17301672
  4. Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies. Bi J, et al. Technol Health Care, 2022. PMID 35124612, Free PMC Article
  5. Pax3 and Pax7 expression during myoblast differentiation in vitro and fast and slow muscle regeneration in vivo. Brzóska E, et al. Cell Biol Int, 2009 Apr. PMID 19101644

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies.
    Title: Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies.
  2. findings show that after optic nerve transection, the number of Pax7-expressing cells increased to re-establish the developmental rostral-caudal gradient and that these Pax7-expressing superior colliculus cells were neurons [Pax7]
    Title: Pax7 expression in the adult rat superior colliculus following optic nerve injury.
  3. Pax7-regulated self-renewal of satellite cells(SC) may be induced during early stage of functional overload and may contribute to modulating SC population in hypertrophied muscles.
    Title: The expression patterns of Pax7 in satellite cells during overload-induced rat adult skeletal muscle hypertrophy.
  4. One possible reason of the depletion of satellite cell pool in prolonged denervated muscle is the down-regulation of Pax7.
    Title: [Pax7 and depletion of satellite cell pool in prolonged denervated skeletal muscles of adult rats].
  5. Pax3 and Pax7, both in vitro and in vivo, participated in the differentiation and regeneration events of muscle
    Title: Pax3 and Pax7 expression during myoblast differentiation in vitro and fast and slow muscle regeneration in vivo.
  6. Pax3 and 7 coordinate the recapitulation of developmental-like regulatory mechanisms in response to growth-inducing stimuli in adult skeletal muscle
    Title: PAX3/7 expression coincides with MyoD during chronic skeletal muscle overload.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron fate commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell fate commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle satellite cell commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spinal cord association neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
paired box protein Pax-7
Names
paired box gene 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191984.2 → NP_001178913.1  paired box protein Pax-7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6ITN1
    Conserved Domains (3) summary
    smart00351
    Location:34 → 159
    PAX; Paired Box domain
    pfam00046
    Location:218 → 272
    Homeobox; Homeobox domain
    pfam12360
    Location:352 → 383
    Pax7; Paired box protein 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    157279623..157381188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239263.5 → XP_006239325.1  paired box protein Pax-7 isoform X1

    UniProtKB/TrEMBL
    A6ITN1, D3ZRA8
    Related
    ENSRNOP00000025488.5
    Conserved Domains (3) summary
    smart00351
    Location:34 → 161
    PAX; Paired Box domain
    pfam00046
    Location:220 → 274
    Homeobox; Homeobox domain
    pfam12360
    Location:354 → 385
    Pax7; Paired box protein 7

  2. XM_063288293.1 → XP_063144363.1  paired box protein Pax-7 isoform X3

  3. XM_039110635.2 → XP_038966563.1  paired box protein Pax-7 isoform X2

    UniProtKB/TrEMBL
    A6ITN1
    Conserved Domains (3) summary
    smart00351
    Location:34 → 160
    PAX; Paired Box domain
    pfam00046
    Location:219 → 273
    Homeobox; Homeobox domain
    pfam12360
    Location:353 → 384
    Pax7; Paired box protein 7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous